Progress Update: Fluid and Imaging Biomarkers in Alzheimer's Disease

被引：22

作者：

Sutphen, Courtney L. ^{[1
,2
,3
]}

Fagan, Anne M. ^{[1
,2
,3
]}

Holtzman, David M. ^{[1
,2
,3
,4
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Charles F & Joanne Knight Alzheimers Dis Res Ctr, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA

来源：

BIOLOGICAL PSYCHIATRY | 2014年 / 75卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; biomarker; cerebrospinal fluid; neuroimaging; diagnosis; prognosis; MILD COGNITIVE IMPAIRMENT; AMYLOID-BETA-PROTEIN; CEREBROSPINAL-FLUID; CSF BIOMARKERS; NATIONAL INSTITUTE; DEFAULT-MODE; TAU-PROTEIN; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; ENTORHINAL CORTEX;

D O I：

10.1016/j.biopsych.2013.07.031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is a growing health crisis around the world. Although significant progress has been made in our understanding of AD pathogenesis, there is currently no effective treatment to delay onset or prevent the disease. The focus has now shifted to the identification and treatment of AD in the early clinical stages as well as before cognitive symptoms emerge-during the long preclinical stage. It is possible that diagnosis of individuals with AD will be more accurate when clinical symptoms and signs are combined with biomarkers, which can improve both the diagnostic and prognostic accuracy of AD and its differentiation from the other neurodegenerative diseases. This review discusses fluid and imaging biomarkers that have shown promise in such areas, as well as some of the current challenges that face the field.

引用

页码：520 / 526

页数：7

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