STAT3: The Key Player in The Network of Inflammation and Cancer

被引：5
作者：
Hou Jia-Jie [1 ]
Sun Bei-Cheng [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Liver Transplantat Ctr, Nanjing 210029, Jiangsu, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2014年 / 41卷 / 01期
关键词：
inflammation; cancer; STAT3; HUMAN HEPATOCELLULAR-CARCINOMA; CELL LUNG-CANCER; SIGNAL TRANSDUCER; COLON-CANCER; SUPPRESSOR-CELLS; TUMOR PROMOTION; GROWTH-FACTOR; KAPPA-B; LINKING INFLAMMATION; LIVER INFLAMMATION;
D O I：
10.3724/SP.J.1206.2013.00462
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Within several decades, the area of inflammation and cancer has attracted great attention. During the process of tumor initiation and progression, a variety of inflammatory cytokines including interleukin-6 entangle tumor cells and the surrounding tumor microenvironment into an inflammatory net; STAT3 (signal transducers and activators of transcription 3) is the key player in the net that persistently promotes tumor development. This review begins with the composition of STAT3 signaling pathways, and discusses its role in different cell types regarding the network between tumor cells and tumor microenvironment, and its advance in translational research on targeted cancer therapy.
引用
收藏
页码：69 / 78
页数：10
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