Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns Findings From the Pregnancy and Childhood Epigenetics Consortium

被引：77

作者：

Kazmi, Nabila ^{[1
,2
]}

Sharp, Gemma C. ^{[1
,2
,3
]}

Reese, Sarah E. ^{[4
]}

Vehmeijer, Florianne O. ^{[5
,6
,7
]}

Lahti, Jari ^{[8
,9
]}

Page, Christian M. ^{[11
,13
]}

Zhang, Weiming ^{[14
]}

Rifas-Shiman, Sheryl L. ^{[18
]}

Rezwan, Faisal I. ^{[19
]}

Simpkin, Andrew J. ^{[1
,21
]}

Burrows, Kimberley ^{[1
,2
]}

Richardson, Tom G. ^{[1
,2
]}

Ferreira, Diana L. Santos ^{[1
,2
]}

Fraser, Abigail ^{[1
,2
]}

Harmon, Quaker E. ^{[4
]}

Zhao, Shanshan ^{[4
]}

Jaddoe, Vincent W. V. ^{[5
,6
,7
]}

Czamara, Darina ^{[22
]}

Binder, Elisabeth B. ^{[22
,23
]}

Magnus, Maria C. ^{[1
,2
,12
]}

Haberg, Siri E. ^{[12
]}

Nystad, Wenche ^{[11
]}

Nohr, Ellen A. ^{[24
]}

Starling, Anne P. ^{[15
]}

Kechris, Katerina J. ^{[14
]}

Yang, Ivana V. ^{[15
,16
,25
]}

DeMeo, Dawn L. ^{[26
]}

Litonjua, Augusto A. ^{[27
]}

Baccarelli, Andrea ^{[28
]}

Oken, Emily ^{[18
]}

Holloway, John W. ^{[19
,20
]}

Karmaus, Wilfried ^{[29
]}

Arshad, Syed H. ^{[20
]}

Dabelea, Dana ^{[15
,17
]}

Sorensen, Thorkild I. A. ^{[1
,30
,31
]}

Laivuori, Hannele ^{[10
,32
,33
,34
,35
,36
]}

Raikkonen, Katri ^{[8
]}

Felix, Janine F. ^{[5
,6
,7
]}

London, Stephanie J. ^{[4
]}

Hivert, Marie-France ^{[18
,37
]}

Gaunt, Tom R. ^{[1
,2
,38
]}

Lawlor, Debbie A. ^{[1
,2
,38
]}

Relton, Caroline L. ^{[1
,2
,38
]}

机构：

[1] Univ Bristol, MRC Integrat Epidemiol Unit, Oakfield House, Bristol BS8 2BN, Avon, England

[2] Univ Bristol, Populat Hlth Sci, Bristol Med Sch, Bristol, Avon, England

[3] Univ Bristol, Sch Oral & Dent Sci, Bristol, Avon, England

[4] NIEHS, Div Intramural Res, Dept Hlth & Human Serv, NIH, Durham, NC USA

[5] Univ Med Ctr, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands

[6] Univ Med Ctr, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[7] Univ Med Ctr, Erasmus MC, Dept Pediat, Rotterdam, Netherlands

[8] Univ Helsinki, Dept Psychol & Logoped, Fac Med, Helsinki, Finland

[9] Univ Helsinki, Helsinki Coll Adv Studies, Helsinki, Finland

[10] Univ Helsinki, Inst Mol Med Finland, Helsinki Inst Life Sci, Helsinki, Finland

[11] Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Oslo, Norway

[12] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway

[13] Oslo Univ Hosp, Oslo Ctr Biostat & Epidemiol, Oslo, Norway

[14] Univ Colorado, Dept Biostat & Informat, Anschutz Med Campus, Aurora, CO USA

[15] Univ Colorado, Dept Epidemiol, Anschutz Med Campus, Aurora, CO USA

[16] Univ Colorado, Dept Med, Anschutz Med Campus, Aurora, CO USA

[17] Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO USA

[18] Harvard Med Sch, Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA 02115 USA

[19] Univ Southampton, Fac Med, Human Dev & Hlth, Southampton, Hants, England

[20] Univ Southampton, Fac Med, Clin & Expt Sci, Southampton, Hants, England

[21] Natl Univ Ireland, Insight Ctr Data Analyt, Galway, Ireland

[22] Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany

[23] Emory Univ, Dept Psychiat & Behav Sci, Sch Med, Atlanta, GA 30322 USA

[24] Univ Southern Denmark, Dept Clin Res, Res Unit Gynaecol & Obstet, Odense, Denmark

[25] Natl Jewish Hlth, Ctr Genes Environm & Hlth, Denver, CO USA

[26] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA

[27] Univ Rochester, Div Pediat Pulm Med, Med Ctr, Rochester, NY 14627 USA

[28] Columbia Univ, Lab Precis Environm Biosci, Mailman Sch Publ Hlth, New York, NY USA

[29] Univ Memphis, Sch Publ Hlth, Div Epidemiol Biostat & Environm Hlth, Memphis, TN 38152 USA

[30] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark

[31] Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Epidemiol Sect, Copenhagen, Denmark

[32] Univ Helsinki, Med & Clin Genet, Helsinki, Finland

[33] Helsinki Univ Hosp, Helsinki, Finland

[34] Univ Tampere, Fac Med & Life Sci, Tampere, Finland

[35] Tampere Univ Hosp, Dept Obstet & Gynecol, Tampere, Finland

[36] Univ Helsinki, Helsinki Inst Life Sci, Inst Mol Med, Helsinki, Finland

[37] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

[38] NIHR Bristol Biomed Res Ctr, Bristol, Avon, England

来源：

HYPERTENSION | 2019年 / 74卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

cardiovascular diseases; DNA methylation; gestational age; hypertension; preeclampsia; BLOOD-PRESSURE; FETAL-GROWTH; NORWEGIAN MOTHER; GENERATION R; COHORT; BIRTH; ASSOCIATIONS; HYPOMETHYLATION; METAANALYSIS; VASOPRESSIN;

D O I：

10.1161/HYPERTENSIONAHA.119.12634

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Hypertensive disorders of pregnancy (HDP) are associated with low birth weight, shorter gestational age, and increased risk of maternal and offspring cardiovascular diseases later in life. The mechanisms involved are poorly understood, but epigenetic regulation of gene expression may play a part. We performed meta-analyses in the Pregnancy and Childhood Epigenetics Consortium to test the association between either maternal HDP (10 cohorts; n=5242 [cases=476]) or preeclampsia (3 cohorts; n=2219 [cases=135]) and epigenome-wide DNA methylation in cord blood using the Illumina HumanMethylation450 BeadChip. In models adjusted for confounders, and with Bonferroni correction, HDP and preeclampsia were associated with DNA methylation at 43 and 26 CpG sites, respectively. HDP was associated with higher methylation at 27 (63%) of the 43 sites, and across all 43 sites, the mean absolute difference in methylation was between 0.6% and 2.6%. Epigenome-wide associations of HDP with offspring DNA methylation were modestly consistent with the equivalent epigenome-wide associations of preeclampsia with offspring DNA methylation (R-2=0.26). In longitudinal analyses conducted in 1 study (n=108 HDP cases; 550 controls), there were similar changes in DNA methylation in offspring of those with and without HDP up to adolescence. Pathway analysis suggested that genes located at/near HDP-associated sites may be involved in developmental, embryogenesis, or neurological pathways. HDP is associated with offspring DNA methylation with potential relevance to development.

引用

页码：375 / 383

页数：9

共 52 条

[1] Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood
Agha, Golareh
Hajj, Hanine
Rifas-Shiman, Sheryl L.
Just, Allan C.
Hivert, Marie-France
Burris, Heather H.
Lin, Xihong
Litonjua, Augusto A.
Oken, Emily
DeMeo, Dawn L.
Gillman, Matthew W.
Baccarelli, Andrea A.
[J]. CLINICAL EPIGENETICS, 2016, 8
[2] DNA Methylation as a Biomarker for Preeclampsia
Anderson, Cindy M.
Ralph, Jody L.
Wright, Michelle L.
Linggi, Bryan
Ohm, Joyce E.
[J]. BIOLOGICAL RESEARCH FOR NURSING, 2014, 16 (04) : 409 - 420
[3] Differential Methylation of Genes Associated with Cell Adhesion in Preeclamptic Placentas
Anton, Lauren
Brown, Amy G.
Bartolomei, Marisa S.
Elovitz, Michal A.
[J]. PLOS ONE, 2014, 9 (06):
[4] Multigenerational cohorts in patients with asthma and allergy
Arshad, S. Hasan
Karmaus, Wilfried
Zhang, Hongmei
Holloway, John W.
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (02) : 415 - 421
[5] Blood Pressure in Different Gestational Trimesters, Fetal Growth, and the Risk of Adverse Birth Outcomes
Bakker, Rachel
Steegers, Eric A. P.
Hofman, Albert
Jaddoe, Vincent W. V.
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2011, 174 (07) : 797 - 806
[6] Pregnancy-induced hypertension and infant growth at 28 and 42 days postpartum
Baulon E.
Fraser W.D.
Piedboeuf B.
Buekens P.
Xiong X.
[J]. BMC Pregnancy and Childbirth, 5 (1)
[7] Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia
Blair, John D.
Yuen, Ryan K. C.
Lim, Brendan K.
McFadden, Deborah E.
von Dadelszen, Peter
Robinson, Wendy P.
[J]. MOLECULAR HUMAN REPRODUCTION, 2013, 19 (10) : 697 - 708
[8] Prediction of gestational age based on genome-wide differentially methylated regions
Bohlin, J.
Haberg, S. E.
Magnus, P.
Reese, S. E.
Gjessing, H. K.
Magnus, M. C.
Parr, C. L.
Page, C. M.
London, S. J.
Nystad, W.
[J]. GENOME BIOLOGY, 2016, 17
[9] Cohort Profile: The 'Children of the 90s'-the index offspring of the Avon Longitudinal Study of Parents and Children
Boyd, Andy
Golding, Jean
Macleod, John
Lawlor, Debbie A.
Fraser, Abigail
Henderson, John
Molloy, Lynn
Ness, Andy
Ring, Susan
Smith, George Davey
[J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2013, 42 (01) : 111 - 127
[10] Expressional and epigenetic alterations of placental serine protease inhibitors -: SERPINA3 is a potential marker of preeclampsia
Chelbi, Sonia T.
Mondon, Francoise
Jammes, Helene
Buffat, Christophe
Mignot, Therese-Marie
Tost, Jorg
Busato, Florence
Gut, Ivo
Rebourcet, Regis
Laissue, Paul
Tsatsaris, Vassili
Goffinet, Francois
Rigourd, Virginie
Carbonne, Bruno
Ferre, Francoise
Vaiman, Daniel
[J]. HYPERTENSION, 2007, 49 (01) : 76 - 83

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