Anticancer Potencies of PtII- and PdII-linked M2L4 Coordination Capsules with Improved Selectivity

被引：63

作者：

Ahmedova, Anife ^{[1
]}

Momekova, Denitsa ^{[2
]}

Yamashina, Masahiro ^{[3
]}

Shestakova, Pavletta ^{[4
]}

Momekov, Georgi ^{[2
]}

Akita, Munetaka ^{[3
]}

Yoshizawa, Michito ^{[3
]}

机构：

[1] Univ Sofia, Fac Chem & Pharm, 1 J Bourchier Blvd, Sofia 1164, Bulgaria

[2] Med Univ Sofia, Fac Pharm, 2 Dunav St, Sofia 1000, Bulgaria

[3] Tokyo Inst Technol, Chem Resources Lab, Midori Ku, 4259 Nagatsuta, Yokohama, Kanagawa 2268503, Japan

[4] Bulgarian Acad Sci, NMR Lab, Inst Organ Chem, Ctr Phytochem, Acad G Bonchev Str,Bl 9, BU-1113 Sofia, Bulgaria

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2016年 / 11卷 / 04期

关键词：

anticancer activity; cancer; cisplatin; coordination capsules; encapsulation; platinum ion; RUTHENIUM HEXACATIONIC PRISM; MOLECULAR CAPSULES; COMPLEXES; WATER; ENCAPSULATION; CYTOTOXICITY; DISCRETE; BINDING; RH(III); CAGES;

D O I：

10.1002/asia.201501238

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pt-II- and Pd-II-linked M2L4 coordination capsules, providing a confined cavity encircled by polyaromatic frameworks, exhibit anticancer activities superior to cisplatin against two types of leukemic cells (HL-60 and SKW-3) and pronounced toxicity against cisplatin-resistant cells (HL-60/CDDP). Notably, the cytotoxic selectivities of the Pt-II and Pd-II capsules toward cancerous cells are up to 5.3-fold higher than that of cisplatin, as estimated through the non-malignant/malignant-cells toxicity ratio employing normal kidney cells (HEK-293). In addition, the anticancer activity of the coordination capsules can be easily altered upon encapsulation of organic guest molecules.

引用

页码：474 / 477

页数：4

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