Anticancer Potencies of PtII- and PdII-linked M2L4 Coordination Capsules with Improved Selectivity

被引：61

作者：

Ahmedova, Anife ^{[1
]}

Momekova, Denitsa ^{[2
]}

Yamashina, Masahiro ^{[3
]}

Shestakova, Pavletta ^{[4
]}

Momekov, Georgi ^{[2
]}

Akita, Munetaka ^{[3
]}

Yoshizawa, Michito ^{[3
]}

机构：

[1] Univ Sofia, Fac Chem & Pharm, 1 J Bourchier Blvd, Sofia 1164, Bulgaria

[2] Med Univ Sofia, Fac Pharm, 2 Dunav St, Sofia 1000, Bulgaria

[3] Tokyo Inst Technol, Chem Resources Lab, Midori Ku, 4259 Nagatsuta, Yokohama, Kanagawa 2268503, Japan

[4] Bulgarian Acad Sci, NMR Lab, Inst Organ Chem, Ctr Phytochem, Acad G Bonchev Str,Bl 9, BU-1113 Sofia, Bulgaria

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2016年 / 11卷 / 04期

关键词：

anticancer activity; cancer; cisplatin; coordination capsules; encapsulation; platinum ion; RUTHENIUM HEXACATIONIC PRISM; MOLECULAR CAPSULES; COMPLEXES; WATER; ENCAPSULATION; CYTOTOXICITY; DISCRETE; BINDING; RH(III); CAGES;

D O I：

10.1002/asia.201501238

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pt-II- and Pd-II-linked M2L4 coordination capsules, providing a confined cavity encircled by polyaromatic frameworks, exhibit anticancer activities superior to cisplatin against two types of leukemic cells (HL-60 and SKW-3) and pronounced toxicity against cisplatin-resistant cells (HL-60/CDDP). Notably, the cytotoxic selectivities of the Pt-II and Pd-II capsules toward cancerous cells are up to 5.3-fold higher than that of cisplatin, as estimated through the non-malignant/malignant-cells toxicity ratio employing normal kidney cells (HEK-293). In addition, the anticancer activity of the coordination capsules can be easily altered upon encapsulation of organic guest molecules.

引用

页码：474 / 477

页数：4

共 57 条

[1] Confined Nanospaces in Metallocages: Guest Molecules, Weakly Encapsulated Anions, and Catalyst Sequestration
Amouri, Hani
Desmarets, Christophe
Moussa, Jamal
[J]. CHEMICAL REVIEWS, 2012, 112 (04) : 2015 - 2041
[2] [Anonymous], ANGEW CHEM
[3] Encapsulation of inorganic and organic guest molecules into an organometallic hexacationic arene osmium metalla-prism: Synthesis, characterisation and anticancer activity
Barry, Nicolas P. E.
Zava, Olivier
Dyson, Paul J.
Therrien, Bruno
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2012, 705 : 1 - 6
[4] Anticancer activity of tetracationic arene ruthenium metalla-cycles
Barry, Nicolas P. E.
Edafe, Fabio
Therrien, Bruno
[J]. DALTON TRANSACTIONS, 2011, 40 (27) : 7172 - 7180
[5] Synthesis, Characterization and Anticancer Activity of Porphyrin-Containing Organometallic Cubes
Barry, Nicolas P. E.
Zava, Olivier
Dyson, Paul J.
Therrien, Bruno
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 2010, 63 (11) : 1529 - 1537
[6] Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104
Benito, Juliana
Shi, Yuexi
Szymanska, Barbara
Carol, Hernan
Boehm, Ingrid
Lu, Hongbo
Konoplev, Sergej
Fang, Wendy
Zweidler-McKay, Patrick A.
Campana, Dario
Borthakur, Gautam
Bueso-Ramos, Carlos
Shpall, Elizabeth
Thomas, Deborah A.
Jordan, Craig T.
Kantarjian, Hagop
Wilson, William R.
Lock, Richard
Andreeff, Michael
Konopleva, Marina
[J]. PLOS ONE, 2011, 6 (08):
[7] Supramolecular Coordination: Self-Assembly of Finite Two- and Three-Dimensional Ensembles
Chakrabarty, Rajesh
Mukherjee, Partha Sarathi
Stang, Peter J.
[J]. CHEMICAL REVIEWS, 2011, 111 (11) : 6810 - 6918
[8] Self-assembled coordination complexes from various palladium(II) components and bidentate or polydentate ligands
Debata, Niladri Bihari
Tripathy, Debakanta
Chand, Dillip Kumar
[J]. COORDINATION CHEMISTRY REVIEWS, 2012, 256 (17-18) : 1831 - 1945
[9] Synthesis, Characterization and Cytotoxicity of (.6-p- cymene) ruthenium(II) Complexes of a- Amino Acids
Egbewande, Folake A.
Paul, Lydia E. H.
Therrien, Bruno
Furrer, Julien
[J]. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2014, 2014 (07) : 1174 - 1184
[10] Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies
Gupta, Gajendra
Nowak-Sliwinska, Patrycja
Herrero, Noelia
Dyson, Paul J.
Therrien, Bruno
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2015, 796 : 59 - 64

← 1 2 3 4 5 6 →