Parathyroid Hormone, A Uremic Toxin

被引：49

作者：

Rodriguez, Mariano ^{[1
]}

Lorenzo, Victor ^{[2
]}

机构：

[1] Univ Cordoba, Hosp Univ Reina Sofia, Unidad Invest, Serv Nefrol, E-14004 Cordoba, Spain

[2] Hosp Univ Tenerife, Serv Nefrol, Tenerife, Spain

来源：

SEMINARS IN DIALYSIS | 2009年 / 22卷 / 04期

关键词：

CHRONIC-RENAL-FAILURE; NERVE CONDUCTION-VELOCITY; SECONDARY HYPERPARATHYROIDISM; HEMODIALYSIS-PATIENTS; TERMINAL FRAGMENTS; CALCIUM; METABOLISM; CELLS; INTACT; ACTIVATION;

D O I：

10.1111/j.1525-139X.2009.00581.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Despite the innovations in the treatment of secondary hyperparathyroidism, there are uremic patients with marked elevation in PTH levels. Uremic toxicity is in part attributable to the excess of circulating PTH. It has been known for many years that PTH may induce changes in cell calcium, a key intracellular signal required for normal cell function. The effect of PTH in dialysis patients is not limited to bone; the diversity of biologic effects of PTH is summarized in this review. In addition, the present review addresses other issues: (i) the presence of different circulating PTH fragments in uremic patients, (ii) the PTH assays currently utilized to measure circulating PTH, and (iii) the fact that some of the PTH effects seen in uremic patients may be due to the interaction of C-terminal PTH fragment with putative C-terminal PTH receptors.

引用

页码：363 / 368

页数：6

共 30 条

[1]

AMANN K, 1994, J AM SOC NEPHROL, V4, P1814

[2] SEARCH FOR UREMIC TOXIN - DECREASED MOTOR-NERVE CONDUCTION-VELOCITY AND ELEVATED PARATHYROID-HORMONE IN UREMIA [J].