New mechanisms by which physical exercise improves insulin resistance in the skeletal muscle

被引：25

作者：

Pauli, Jose Rodrigo ^{[1
,2
]}

Cintra, Dennys Esper ^{[2
]}

de Souza, Claudio Teodoro ^{[3
]}

Ropelle, Eduardo Rochette ^{[2
]}

机构：

[1] Univ Fed Sao Paulo Unifesp, Dept Biociencias, Curso Educ Fis Modalidade Saude, Fac Educ Fis, BR-11060001 Santos, SP, Brazil

[2] Univ Estadual Campinas, UNICAMP, Fac Ciencias Med, Dept Clin Med, Campinas, Brazil

[3] Univ Extremo Catarinense, Lab Fisiol & Bioquim Exercicio, Programa Posgrad Ciencias Saude, Criciuma, SC, Brazil

来源：

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2009年 / 53卷 / 04期

关键词：

Exercise; insulin resistance; inflammation; skeletal muscle; ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; GLUCOSE-TRANSPORT; S-NITROSATION; LIPID-METABOLISM; FATTY-ACIDS; LIFE-STYLE; OBESITY; RECEPTOR; INFLAMMATION;

D O I：

10.1590/S0004-27302009000400003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance of skeletal muscle glucose transport is a key-defect for the development of impaired glucose tolerance and type 2 diabetes. However, it is known that both an acute bout of exercise and chronic endurance exercise training can bring beneficial effects on insulin action in insulin-resistant states. However, little is currently known about the molecular effects of acute exercise on muscle insulin signaling in the post-exercise state in insulin-resistant organisms. This review provides new insight into the mechanism through which acute exercise restores insulin sensitivity, highlighting an important role for inflammatory proteins and S-nitrosation in the regulation of insulin signaling proteins in skeletal muscle. Arq Bras Endocrinol Metab. 2009; 53(4): 399-408.

引用

页码：399 / 408

页数：10

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