Diverse transport modes by the solute carrier 26 family of anion transporters

被引：102

作者：

Ohana, Ehud ^{[1
]}

Yang, Dongki ^{[1
]}

Shcheynikov, Nikolay ^{[1
]}

Muallem, Shmuel ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2009年 / 587卷 / 10期

关键词：

DYSPLASIA SULFATE TRANSPORTER; PENDRED-SYNDROME GENE; CL-/HCO3-EXCHANGE; BASOLATERAL MEMBRANE; HCO3-SECRETION; ADENOMA DRA; SLC26A6; RAT; MUTATIONS; CHANNEL;

D O I：

10.1113/jphysiol.2008.164863

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The solute carrier 26 (SLC26) transporters are anion transporters with diverse substrate specificity. Several members are ubiquitous while others show limited tissue distribution. They are expressed in many epithelia and to the extent known, play a central role in anion secretion and absorption. Members of the family are primarily Cl- transporters, although some members transport mainly SO42-, Cl-, HCO3- or I-. A defining feature of the family is their functional diversity. Slc26a1 and Slc26a2 function as specific SO42- transporters while Slc26a4 functions as an electroneutral Cl-/I-/HCO3- exchanger. Slc26a3 and Slc26a6 function as coupled electrogenic Cl-/HCO3- exchangers or as bona fide anion channels. SLC26A7 and SLC26A9 function exclusively as Cl- channels. This short review discusses the functional diversity of the SLC26 transporters.

引用

页码：2179 / 2185

页数：7

共 55 条

[1] Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels [J].

Accardi, A ;

Kolmakova-Partensky, L ;

Williams, C ;

Miller, C .

JOURNAL OF GENERAL PHYSIOLOGY, 2004, 123 (02) :109-119

[2] Carbachol increases Na+-HCO3- cotransport activity in murine colonic crypts in a M3-, Ca2+/calmodulin-, and PKC-dependent manner [J].

Bachmann, O. ;

Reichelt, D. ;

Tuo, B. ;

Manns, M. P. ;

Seidler, U. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2006, 291 (04) :G650-G657

[3]

BISSIG M, 1994, J BIOL CHEM, V269, P3017

[4] Ion and liquid transport across the bronchiolar epithelium [J].

Blouquit-Laye, Sabine ;

Chinet, Thierry .

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2007, 159 (03) :278-282

[5] Pendred syndrome, DFNB4, and PDS/SCL26A4 identification of eight novel mutations and possible genotype-phenotype correlations [J].

Campbell, C ;

Cucci, RA ;

Prasad, S ;

Green, GE ;

Edeal, JB ;

Galer, CE ;

Karniski, LP ;

Sheffield, VC ;

Smith, RJH .

HUMAN MUTATION, 2001, 17 (05) :403-411

[6] An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel [J].

Choi, I ;

Aalkjaer, C ;

Boulpaep, EL ;

Boron, WF .

NATURE, 2000, 405 (6786) :571-575

[7] Pendred syndrome (goitre and sensorineural hearing loss) maps to chromosome 7 in the region containing the nonsyndromic deafness gene DFNB4 [J].

Coyle, B ;

Coffey, R ;

Armour, JAL ;

Gausden, E ;

Hochberg, Z ;

Grossman, A ;

Britton, K ;

Pembrey, M ;

Reardon, W ;

Trembath, R .

NATURE GENETICS, 1996, 12 (04) :421-423

[8] Conserved dimeric subunit stoichiometry of SLC26 multifunctional anion exchangers [J].

Detro-Dassen, Silvia ;

Schaenzler, Michael ;

Lauks, Heike ;

Martin, Ina ;

zu Berstenhorst, Sonja Meyer ;

Nothmann, Doreen ;

Torres-Salazar, Delany ;

Hidalgo, Patricia ;

Schmalzing, Guenther ;

Fahlke, Christoph .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (07) :4177-4188

[9] The solute carrier 26 family of proteins in epithelial ion transport [J].

Dorwart, Michael R. ;

Shcheynikov, Nikolay ;

Yang, Dongki ;

Muallem, Shmuel .

PHYSIOLOGY, 2008, 23 (02) :104-114

[10] SLC26A9 is a Cl- channel regulated by the WNK kinases [J].

Dorwart, Michael R. ;

Shcheynikov, Nikolay ;

Wang, Youxue ;

Stippec, Steve ;

Muallem, Shmuel .

JOURNAL OF PHYSIOLOGY-LONDON, 2007, 584 (01) :333-345

← 1 2 3 4 5 6 →