Tissue-resident memory T cells: local specialists in immune defence

被引：753
作者：
Mueller, Scott N. [1 ,2 ]
Mackay, Laura K. [1 ,2 ]
机构：
[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia
[2] Univ Melbourne, Australian Res Council Ctr Excellence Adv Mol Ima, Melbourne, Vic 3000, Australia
来源：
NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 02期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
CUTTING EDGE; PROMOTES DIFFERENTIATION; PROTECTIVE IMMUNITY; LYMPHOID ORGANS; INFLUENZA-VIRUS; E-CADHERIN; RM CELLS; EFFECTOR; SKIN; MIGRATION;
D O I：
10.1038/nri.2015.3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T cells have crucial roles in protection against infection and cancer. Although the trafficking of memory T cells around the body is integral to their capacity to provide immune protection, studies have shown that specialization of some memory T cells into unique tissue-resident subsets gives the host enhanced regional immunity. In recent years, there has been considerable progress in our understanding of tissue-resident T cell development and function, revealing mechanisms for enhanced protective immunity that have the potential to influence rational vaccine design. This Review discusses the major advances and the emerging concepts in this field, summarizes what is known about the differentiation and the protective functions of tissue-resident memory T cells in different tissues in the body and highlights key unanswered questions.
引用
收藏
页码：79 / 89
页数：11
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