Synthesis of carbon-11 labeled triphenylacetamides as novel potential PET melanoma cancer imaging agents

被引：3

作者：

Gao, Mingzhang

Kong, Deyuan

Clearfield, Abraham

Miller, Kathy D.

Sledge, George W.

Zheng, Qi-Huang ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

[3] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA

来源：

SYNTHESIS-STUTTGART | 2006年 / 14期

关键词：

triphenylacetamides; N-(4-[C-11]methoxyphenyl)-2,2,2-triphenylacetamide; 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [C-11]methyl ester; positron emission tomography; melanoma cancer; imaging agents;

D O I：

10.1055/s-2006-942442

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New carbon-11 labeled triphenylacetamides (TPAs), N-(4-[C-11]methoxyphenyl)-2,2,2-triphenyl-acetamide ([C-11]MTA) and 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [C-11]methyl ester ([C-11]PAME), were designed and synthesized as potential positron emission tomography (PET) melanoma cancer imaging agents. The single crystal structure of the potent anti-melanoma agent, N-(4-methoxyphenyl)-2,2,2-triphenylacetamide (MTA) is reported.

引用

页码：2301 / 2304

页数：4

共 7 条

[1] Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest
Dothager, RS
Putt, KS
Allen, BJ
Leslie, BJ
Nesterenko, V
Hergenrother, PJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (24) : 8686 - 8696
[2] Mock BH, 2005, J LABELLED COMPD RAD, V48, pS225
[3] Mock BH, 2005, J LABELLED COMPD RAD, V48, pS224
[4] Convenient gas phase bromination of [11C]methane and production of [11C]methyl triflate
Mock, BH
Mulholland, GK
Vavrek, MT
[J]. NUCLEAR MEDICINE AND BIOLOGY, 1999, 26 (04) : 467 - 471
[5] HARD ACID AND SOFT NUCLEOPHILE SYSTEM .2. DEMETHYLATION OF METHYL ETHERS OF ALCOHOL AND PHENOL WITH AN ALUMINUM HALIDE-THIOL SYSTEM
NODE, M
NISHIDE, K
FUJI, K
FUJITA, E
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (22) : 4275 - 4277
[6] Purification of carbon-11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE
Zheng, QH
Mock, BH
[J]. BIOMEDICAL CHROMATOGRAPHY, 2005, 19 (09) : 671 - 676
[7] Improved synthesis of beta-CIT and [C-11]beta-CIT labeled at nitrogen or oxygen positions
Zheng, QH
Mulholland, GK
[J]. NUCLEAR MEDICINE AND BIOLOGY, 1996, 23 (08): : 981 - 986

← 1 →