Mass Spectrometry for Synthesis and Analysis

被引:44
作者
Cooks, R. Graham [1 ]
Yan, Xin [1 ,2 ]
机构
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47906 USA
[2] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
来源
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 11 | 2018年 / 11卷
关键词
ion chemistry; molecular imaging; cancer diagnostics; origin of life; ion soft landing; reaction monitoring; ambient ionization; accelerated reactions; DESORPTION ELECTROSPRAY-IONIZATION; SURFACE-INDUCED DISSOCIATION; CARBON BOND ACTIVATION; HUMAN BRAIN-TUMORS; GAS-PHASE; SECONDARY-ION; PROSTATE-CANCER; SERINE OCTAMER; THERMOCHEMICAL PROPERTIES; ORGANIC-MOLECULES;
D O I
10.1146/annurev-anchem-061417-125820
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Mass spectrometry is the science and technology of ions. As such, it is concerned with generating ions, measuring their properties, following their reactions, isolating them, and using them to build and transform materials. Instrumentation is an essential element of these activities, and analytical applications are one driving force. Work from the Aston Laboratories at Purdue University's Department of Chemistry is described here, with an emphasis on accelerated reactions of ions in solution and small-scale synthesis; ion/surface collision processes, including surface-induced dissociation (SID) and ion soft landing; and applications to tissue imaging. Our special interest in chirality and the chemistry behind the origins of life is also featured together with the exciting area of tissue diagnostics.
引用
收藏
页码:1 / 28
页数:28
相关论文
共 148 条
[41]   Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors [J].
Eberlin, Livia S. ;
Norton, Isaiah ;
Orringer, Daniel ;
Dunn, Ian F. ;
Liu, Xiaohui ;
Ide, Jennifer L. ;
Jarmusch, Alan K. ;
Ligon, Keith L. ;
Jolesz, Ferenc A. ;
Golby, Alexandra J. ;
Santagata, Sandro ;
Agar, Nathalie Y. R. ;
Cooks, R. Graham .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (05) :1611-1616
[42]   Classifying Human Brain Tumors by Lipid Imaging with Mass Spectrometry [J].
Eberlin, Livia S. ;
Norton, Isaiah ;
Dill, Allison L. ;
Golby, Alexandra J. ;
Ligon, Keith L. ;
Santagata, Sandro ;
Cooks, R. Graham ;
Agar, Nathalie Y. R. .
CANCER RESEARCH, 2012, 72 (03) :645-654
[43]   Discrimination of Human Astrocytoma Subtypes by Lipid Analysis Using Desorption Electrospray Ionization Imaging Mass Spectrometry [J].
Eberlin, Livia S. ;
Dill, Allison L. ;
Golby, Alexandra J. ;
Ligon, Keith L. ;
Wiseman, Justin M. ;
Cooks, R. Graham ;
Agar, Nathalie Y. R. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (34) :5953-5956
[44]   Cholesterol Sulfate Imaging in Human Prostate Cancer Tissue by Desorption Electrospray Ionization Mass Spectrometry [J].
Eberlin, Livia S. ;
Dill, Allison L. ;
Costa, Anthony B. ;
Ifa, Demian R. ;
Cheng, Liang ;
Masterson, Timothy ;
Koch, Michael ;
Ratliff, Timothy L. ;
Cooks, R. Graham .
ANALYTICAL CHEMISTRY, 2010, 82 (09) :3430-3434
[45]   Enhanced Chemical Synthesis at Soft Interfaces: A Universal Reaction-Adsorption Mechanism in Microcompartments [J].
Fallah-Araghi, Ali ;
Meguellati, Kamel ;
Baret, Jean-Christophe ;
El Harrak, Abdeslam ;
Mangeat, Thomas ;
Karplus, Martin ;
Ladame, Sylvain ;
Marques, Carlos M. ;
Griffiths, Andrew D. .
PHYSICAL REVIEW LETTERS, 2014, 112 (02)
[46]   ELECTROSPRAY IONIZATION FOR MASS-SPECTROMETRY OF LARGE BIOMOLECULES [J].
FENN, JB ;
MANN, M ;
MENG, CK ;
WONG, SF ;
WHITEHOUSE, CM .
SCIENCE, 1989, 246 (4926) :64-71
[47]   Electrospray wings for molecular elephants (Nobel lecture) [J].
Fenn, JB .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (33) :3871-3894
[48]   Chemical profiling of cerebrospinal fluid by multiple reaction monitoring mass spectrometry [J].
Ferreira, Christina R. ;
Yannell, Karen E. ;
Mollenhauer, Brit ;
Espy, Ryan D. ;
Cordeiro, Fernanda B. ;
Ouyang, Z. ;
Cooks, R. G. .
ANALYST, 2016, 141 (18) :5252-5255
[49]   Label free biochemical 2D and 3D imaging using secondary ion mass spectrometry [J].
Fletcher, John S. ;
Vickerman, John C. ;
Winograd, Nicholas .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2011, 15 (05) :733-740
[50]   SOFT LANDING OF IONS AS A MEANS OF SURFACE MODIFICATION [J].
FRANCHETTI, V ;
SOLKA, BH ;
BAITINGER, WE ;
AMY, JW ;
COOKS, RG .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1977, 23 (01) :29-35