Utilization of supercritical carbon dioxide for the preparation of 3-hydroxyflavone and β-cyclodextrin complex

被引：10
|
作者：
Wang, Bo [1 ]
He, Jun [1 ]
Sun, Donghai [1 ]
Zhang, Rui [1 ]
Han, Buxing [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2006年 / 55卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
beta-cyclodextrin; inclusion complex; 3-hydroxyflavone; supercritical carbon dioxide;
D O I：
10.1007/s10847-005-9015-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The solubility of 3-hydroxyflavone in water can be enhanced by forming complex with beta-cyclodextrin (beta-CD). In this study we introduced supercritical carbon dioxide as a substitute solvent to prepare 3-hydroxyflavone-beta-cyclodextrin complex. The maximum drug loading determined by UV spectroscopy in complex was 14.7 wt.%, which was comparable to that of 1: 1 complex (17.34 wt.% of 3-hydroxyflavone). The solubility of the drug loaded in the complex was better than that of pure drug in water. The enhanced solubility was attributed to the formation of the complex and the solubility of the beta-cyclodextrin in water.
引用
收藏
页码：37 / 40
页数：4
相关论文
共 50 条
  • [41] Complex of shikonin and β-cyclodextrins by using supercritical carbon dioxide
    He, Jun
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2009, 63 (3-4) : 249 - 255
  • [42] Optimisation of Supercritical Carbon Dioxide Systems for Complexation of Naproxen : Beta-Cyclodextrin
    Susana Junco
    Teresa Casimiro
    Nuno Ribeiro
    Manuel Nunes Da Ponte
    Helena M. Cabral Marques
    Journal of inclusion phenomena and macrocyclic chemistry, 2002, 44 : 69 - 73
  • [43] Development of fluorescent FRET probe for determination of glucose based on β-cyclodextrin modified ZnS-quantum dots and natural pigment 3-hydroxyflavone
    Dong, Ling-Yu
    Wang, Li-Yun
    Wang, Xiang-Fang
    Liu, Yuan
    Liu, Hai-Ling
    Xie, Meng-Xia
    DYES AND PIGMENTS, 2016, 128 : 170 - 178
  • [44] A comparative study of naproxen - Beta cyclodextrin complexes prepared by conventional methods and using Supercritical carbon dioxide
    Junco, S
    Casimiro, T
    Ribeiro, N
    Da Ponte, MN
    Marques, HC
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2002, 44 (1-4) : 117 - 121
  • [45] Physicochemical characterizations of safranal-β-cyclodextrin inclusion complexes prepared by supercritical carbon dioxide and conventional methods
    Abbaszadegan, Sanaz
    Al-Marzouqi, Ali H.
    Salem, Alaa A.
    Amin, Amr
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2015, 83 (3-4) : 215 - 226
  • [46] The preparation of gold nanoparticle composites using supercritical carbon dioxide
    Wong, Ben
    Yoda, Satoshi
    Howdle, Steven M.
    JOURNAL OF SUPERCRITICAL FLUIDS, 2007, 42 (02) : 282 - 287
  • [47] Preparation of TiO2 nanoparticles by supercritical carbon dioxide
    Wu, Chen-I
    Huang, Jiann-Wen
    Wen, Ya-Lan
    Wen, Shaw-Bing
    Shen, Yun-Hwei
    Yeh, Mou-Yung
    MATERIALS LETTERS, 2008, 62 (12-13) : 1923 - 1926
  • [48] Preparation of aromatic polycarbonate nanoparticles using supercritical carbon dioxide
    Lee, JY
    Song, CH
    Kim, JI
    Kim, JH
    JOURNAL OF NANOPARTICLE RESEARCH, 2002, 4 (1-2) : 53 - 59
  • [49] Preparation of silica sphere with porous structure in supercritical carbon dioxide
    Chatterjee, Maya
    Chatterjee, Abhijit
    Ikushima, Yutaka
    Kawanami, Hajime
    Ishizaka, Takayuki
    Sato, Masahiro
    Suzuki, Toshishige
    Yokoyama, Toshirou
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2010, 348 (01) : 57 - 64
  • [50] Preparation of silicone rubber foam using supercritical carbon dioxide
    Song, Lixian
    Lu, Ai
    Feng, Peijie
    Lu, Zhongyuan
    MATERIALS LETTERS, 2014, 121 : 126 - 128
12345