Utilization of supercritical carbon dioxide for the preparation of 3-hydroxyflavone and β-cyclodextrin complex

被引：10
|
作者：
Wang, Bo [1 ]
He, Jun [1 ]
Sun, Donghai [1 ]
Zhang, Rui [1 ]
Han, Buxing [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2006年 / 55卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
beta-cyclodextrin; inclusion complex; 3-hydroxyflavone; supercritical carbon dioxide;
D O I：
10.1007/s10847-005-9015-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The solubility of 3-hydroxyflavone in water can be enhanced by forming complex with beta-cyclodextrin (beta-CD). In this study we introduced supercritical carbon dioxide as a substitute solvent to prepare 3-hydroxyflavone-beta-cyclodextrin complex. The maximum drug loading determined by UV spectroscopy in complex was 14.7 wt.%, which was comparable to that of 1: 1 complex (17.34 wt.% of 3-hydroxyflavone). The solubility of the drug loaded in the complex was better than that of pure drug in water. The enhanced solubility was attributed to the formation of the complex and the solubility of the beta-cyclodextrin in water.
引用
收藏
页码：37 / 40
页数：4
相关论文
共 50 条
  • [31] Preparation of nanoporous polyolefin films in supercritical carbon dioxide
    Trofimchuk, E. S.
    Efimov, A. V.
    Nikitin, L. N.
    Nikonorova, N. I.
    Volynskii, A. L.
    Khokhlov, A. R.
    Bakeev, N. F.
    RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B, 2014, 8 (08) : 1019 - 1024
  • [32] Preparation of molecularly imprinted polymers in supercritical carbon dioxide
    Ye, Lei
    Yoshimatsu, Keiichi
    Kolodziej, Dorota
    Da Cruz Francisco, Jose
    Dey, Estera S.
    JOURNAL OF APPLIED POLYMER SCIENCE, 2006, 102 (03) : 2863 - 2867
  • [33] Preparation of nanoporous polyolefin films in supercritical carbon dioxide
    E. S. Trofimchuk
    A. V. Efimov
    L. N. Nikitin
    N. I. Nikonorova
    A. L. Volynskii
    A. R. Khokhlov
    N. F. Bakeev
    Russian Journal of Physical Chemistry B, 2014, 8 : 1019 - 1024
  • [34] Preparation of polystyrene/montmorillonite nanocomposites in supercritical carbon dioxide
    Yan, C
    Ma, L
    Yang, JC
    JOURNAL OF APPLIED POLYMER SCIENCE, 2005, 98 (01) : 22 - 28
  • [35] Preparation of Microcellular Polyurethane Using Supercritical Carbon Dioxide
    Ito, Shunsuke
    Miura, Hideaki
    Tajima, Masahiro
    Matsunaga, Katsuji
    KOBUNSHI RONBUNSHU, 2008, 65 (04) : 309 - 311
  • [36] Preparation of noble metal nanoparticles in supercritical carbon dioxide
    Kameo, A
    Yoshimura, T
    Esumi, K
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2003, 215 (1-3) : 181 - 189
  • [37] Complex of shikonin and β-cyclodextrins by using supercritical carbon dioxide
    Jun He
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2009, 63 : 249 - 255
  • [38] Treatment of discarded oil in supercritical carbon dioxide for preparation of carbon microspheres
    Binxing Yu
    Xiangkai Kong
    Lingzhi Wei
    Qianwang Chen
    Journal of Material Cycles and Waste Management, 2011, 13 : 298 - 304
  • [39] Preparation of liposomes using supercritical carbon dioxide via depressurization of the supercritical phase
    Zhao, Lisha
    Temelli, Feral
    JOURNAL OF FOOD ENGINEERING, 2015, 158 : 104 - 112
  • [40] Treatment of discarded oil in supercritical carbon dioxide for preparation of carbon microspheres
    Yu, Binxing
    Kong, Xiangkai
    Wei, Lingzhi
    Chen, Qianwang
    JOURNAL OF MATERIAL CYCLES AND WASTE MANAGEMENT, 2011, 13 (04) : 298 - 304
12345