Antibacterial prenylflavone derivatives from Psoralea corylifolia, and their structure-activity relationship study

被引：192

作者：

Yin, S ^{[1
]}

Fan, CQ ^{[1
]}

Wang, Y ^{[1
]}

Dong, L ^{[1
]}

Yue, JM ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 16期

关键词：

Psoralea corylifolia; Fabaceae; corylifols A-C; antibacterial activity; structure-activity relationship;

D O I：

10.1016/j.bmc.2004.06.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new prenylflavonoids, namely corylifols A-C (1-3), together with 13 known ones, were isolated from the seeds of Psoralea corylifolia. Their structures were elucidated by spectral methods including 1D and 2D NMR techniques. All the isolates were tested on antibacterial assays, and nine of them showed significant antibacterial activities against two pathogenic bacteria Staphylococcus aureus and S. epidermidis. The antibacterial structure-activity relationship of these prenylflavonoids (1-16) was also briefly discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4387 / 4392

页数：6

共 19 条

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[2]

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