The molecular pathogenesis of mantle cell lymphoma

被引：41

作者：

Vogt, Niklas ^{[1
,2
]}

Dai, Beiying ^{[1
,3
]}

Erdmann, Tabea ^{[1
,3
]}

Berdel, Wolfgang E. ^{[2
,3
]}

Lenz, Georg ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Munster, Dept Translat Oncol, Munster, Germany

[2] Univ Hosp Munster, Dept Med Hematol Oncol & Pneumol A, Munster, Germany

[3] Deutsch Forsch Gemeinschaft EXC 1003, Cluster Excellence, Cells Mot, Munster, Germany

来源：

LEUKEMIA & LYMPHOMA | 2017年 / 58卷 / 07期

基金：

瑞士国家科学基金会;

关键词：

Mantle cell lymphoma; molecular pathogenesis; translocation; KAPPA-B ACTIVATION; GENE-EXPRESSION; CYCLIN D1; RANDOMIZED-TRIALS; MUTATIONS; PATHWAY; INHIBITION; BORTEZOMIB; REVEALS; GROWTH;

D O I：

10.1080/10428194.2016.1248965

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mantle cell lymphoma (MCL) is characterized by the translocation t(11; 14) leading to constitutive cyclin D1 overexpression. However, overexpression of cyclin D1 alone is insufficient to cause malignant transformation. Secondary genetic alterations and deregulated signaling pathways involved in DNA damage response, cell proliferation, and apoptosis are indispensable for MCL lymphomagenesis. Recent studies investigating the biology of MCL have revealed crucial importance of B-cell receptor (BCR), nuclear factor-kappa B (NF-kappa B), phosphoinositide 3-kinase (PI3K), and BCL2 signaling for the molecular pathogenesis of MCL. In addition, activation of the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3), NOTCH and WNT pathway can be observed in subsets of MCLs. These addictions can potentially be utilized therapeutically by implementing small molecule inhibitors into current treatment regimens.

引用

页码：1530 / 1537

页数：8

共 75 条

[1] The Bcl-2 apoptotic switch in cancer development and therapy [J].

Adams, J. M. ;

Cory, S. .

ONCOGENE, 2007, 26 (09) :1324-1337

[2] Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase [J].

Aggarwal, Priya ;

Vaites, Laura Pontano ;

Kim, Jong Kyong ;

Mellert, Hestia ;

Gurung, Buddha ;

Nakagawa, Hiroshi ;

Herlyn, Meenhard ;

Hua, Xianxin ;

Rustgi, Anil K. ;

McMahon, Steven B. ;

Diehl, J. Alan .

CANCER CELL, 2010, 18 (04) :329-340

[3] WNT signalling pathways as therapeutic targets in cancer [J].

Anastas, Jamie N. ;

Moon, Randall T. .

NATURE REVIEWS CANCER, 2013, 13 (01) :11-26

[4] Constitutive and B-cell receptor-induced activation of STAT3 are important signaling pathways targeted by bortezomib in leukemic mantle cell lymphoma [J].

Baran-Marszak, Fanny ;

Boukhiar, Mohand ;

Harel, Stephanie ;

Laguillier, Christelle ;

Roger, Claudine ;

Gressin, Remy ;

Martin, Antoine ;

Fagard, Remi ;

Varin-Blank, Nadine ;

Ajchenbaum-Cymbalista, Florence ;

Ledoux, Dominique .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 (11) :1865-1872

[5] Outcomes with adjuvant chemo-radiation (ACRT) in patients (pts) with localized gastric cancer (GC): Analysis of National Cancer Data Base (NCDB) [J].

Barzi, Afsaneh ;

Yang, Dongyun ;

Lenz, Heinz-Josef ;

Sadeghi, Sarmad .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)

[6]

Beà S, 2001, CANCER RES, V61, P2409

[7] Landscape of somatic mutations and clonal evolution in mantle cell lymphoma [J].

Bea, Silvia ;

Valdes-Mas, Rafael ;

Navarro, Alba ;

Salaverria, Itziar ;

Martin-Garcia, David ;

Jares, Pedro ;

Gine, Eva ;

Pinyol, Magda ;

Royo, Cristina ;

Nadeu, Ferran ;

Conde, Laura ;

Juan, Manel ;

Clot, Guillem ;

Vizan, Pedro ;

Di Croce, Luciano ;

Puente, Diana A. ;

Lopez-Guerra, Monica ;

Moros, Alexandra ;

Roue, Gael ;

Aymerich, Marta ;

Villamor, Neus ;

Colomo, Lluis ;

Martinez, Antonio ;

Valera, Alexandra ;

Martin-Subero, Jose I. ;

Amador, Virginia ;

Hernandez, Luis ;

Rozman, Maria ;

Enjuanes, Anna ;

Forcada, Pilar ;

Muntanola, Ana ;

Hartmann, Elena M. ;

Calasanz, Maria J. ;

Rosenwald, Andreas ;

Ott, German ;

Hernandez-Rivas, Jesus M. ;

Klapper, Wolfram ;

Siebert, Reiner ;

Wiestner, Adrian ;

Wilson, Wyndham H. ;

Colomer, Dolors ;

Lopez-Guillermo, Armando ;

Lopez-Otin, Carlos ;

Puente, Xose S. ;

Campo, Elias .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (45) :18250-18255

[8] Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling [J].

Bea, Silvia ;

Salaverria, Itziar ;

Armengol, Lluis ;

Pinyol, Magda ;

Fernandez, Veronica ;

Hartmann, Elena M. ;

Jares, Pedro ;

Amador, Virginia ;

Hernandez, Luis ;

Navarro, Alba ;

Ott, German ;

Rosenwald, Andreas ;

Estivill, Xavier ;

Campo, Elias .

BLOOD, 2009, 113 (13) :3059-3069

[9] Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen [J].

Bienvenu, Frederic ;

Jirawatnotai, Siwanon ;

Elias, Joshua E. ;

Meyer, Clifford A. ;

Mizeracka, Karolina ;

Marson, Alexander ;

Frampton, Garrett M. ;

Cole, Megan F. ;

Odom, Duncan T. ;

Odajima, Junko ;

Geng, Yan ;

Zagozdzon, Agnieszka ;

Jecrois, Marie ;

Young, Richard A. ;

Liu, X. Shirley ;

Cepko, Constance L. ;

Gygi, Steven P. ;

Sicinski, Piotr .

NATURE, 2010, 463 (7279) :374-378

[10] CYCLIN D1 TRANSGENE IMPEDES LYMPHOCYTE MATURATION AND COLLABORATES IN LYMPHOMAGENESIS WITH THE MYC GENE [J].

BODRUG, SE ;

WARNER, BJ ;

BATH, ML ;

LINDEMAN, GJ ;

HARRIS, AW ;

ADAMS, JM .

EMBO JOURNAL, 1994, 13 (09) :2124-2130

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