Human papillomavirus (HPV) deregulation of Toll-like receptor 9

被引：21

作者：

Hasan, Uzma ^{[1
]}

机构：

[1] Univ Lyon, Hosp Civils Lyon, Ecole Normale Super, INSERM U1111,CNRS UMR5308,CIRI, Lyon, France

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期

关键词：

E7; HPV16; immunosuppression; TLR9; CERVICAL-CANCER; RECOGNITION; EXPRESSION; TYPE-16; TLR9;

D O I：

10.4161/onci.27257

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Persistent infection by high- risk human papillomavirus (HPV) is associated with cervical carcinoma. Blocking innate immune responses in the cervix is critical for the establishment of persistent infections. Here, we discuss how HPV-16-encoded factors suppress the activity of Toll-like receptor 9, which plays a major role in innate antiviral immune responses.

引用

页数：3

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