Human papillomavirus (HPV) deregulation of Toll-like receptor 9

被引：21
|
作者：
Hasan, Uzma [1 ]
机构：
[1] Univ Lyon, Hosp Civils Lyon, Ecole Normale Super, INSERM U1111,CNRS UMR5308,CIRI, Lyon, France
来源：
ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期
关键词：
E7; HPV16; immunosuppression; TLR9; CERVICAL-CANCER; RECOGNITION; EXPRESSION; TYPE-16; TLR9;
D O I：
10.4161/onci.27257
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Persistent infection by high- risk human papillomavirus (HPV) is associated with cervical carcinoma. Blocking innate immune responses in the cervix is critical for the establishment of persistent infections. Here, we discuss how HPV-16-encoded factors suppress the activity of Toll-like receptor 9, which plays a major role in innate antiviral immune responses.
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页数：3
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