Are isothiocyanates potential anti-cancer drugs?

被引：197

作者：

Wu, Xiang ^{[1
]}

Zhou, Qing-hua ^{[1
]}

Xu, Ke ^{[1
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Tianjin Lung Canc Inst, Tianjin Key Lab Lung Canc Metastasis & Tumor Micr, Tianjin 300052, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 2009年 / 30卷 / 05期

基金：

中国国家自然科学基金;

关键词：

isothiocyanate; chemoprevention; anticarcinogenic; antitumor; apoptosis; cell cycle; CELL-CYCLE ARREST; DNA ADDUCT FORMATION; PHENETHYL ISOTHIOCYANATE; BENZYL ISOTHIOCYANATE; 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE METABOLISM; CHEMOPREVENTIVE ISOTHIOCYANATES; ARYLALKYL ISOTHIOCYANATES; ESOPHAGEAL TUMORIGENESIS; DIETARY ISOTHIOCYANATES; CRUCIFEROUS VEGETABLES;

D O I：

10.1038/aps.2009.50

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic, display anticarcinogenic activity because they reduce activation of carcinogens and increase their detoxification. Recent studies show that they exhibit anti-tumor activity by affecting multiple pathways including apoptosis, MAPK signaling, oxidative stress, and cell cycle progression. This review summarizes the current knowledge on isothiocyanates and focuses on their role as potential anti-cancer agents.

引用

页码：501 / 512

页数：12

共 70 条

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