Is age-related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment

被引：94

作者：

Cheung, C. M. G. ^{[1
,2
,3
]}

Wong, T. Y. ^{[1
,2
,3
,4
]}

机构：

[1] Singapore Natl Eye Ctr, Singapore 168751, Singapore

[2] Singapore Eye Res Inst, Singapore, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 117595, Singapore

[4] Duke NUS Grad Med Sch, Ophthalmol Acad Clin Program, Singapore, Singapore

来源：

JOURNAL OF INTERNAL MEDICINE | 2014年 / 276卷 / 02期

关键词：

age-related macular degeneration; pathogenesis; risk factors; treatment; COMPLEMENT-FACTOR-H; ENDOTHELIAL GROWTH-FACTOR; C-REACTIVE PROTEIN; POLYPOIDAL CHOROIDAL VASCULOPATHY; LONG-TERM INCIDENCE; CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; ATHEROSCLEROSIS RISK; 10-YEAR INCIDENCE;

D O I：

10.1111/joim.12227

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Age-related macular degeneration (AMD) is a common vision-threatening condition affecting the elderly. AMD shares common risk factors and processes, including vascular and inflammatory pathways, with many systemic disorders. Associations have been reported between AMD and hypertension, cardiovascular disease, cerebrovascular disease, dyslipidaemia, chronic kidney disease and neurodegenerative disorders. An increasing amount of evidence suggests that individuals with AMD are also at risk of systemic diseases such as stroke. In this review, we summarize the latest evidence to support the notion that AMD is an ocular manifestation of systemic disease processes, and discuss the potential systemic side effects of ocular AMD therapy of which general physicians should be aware. Recent genetic discoveries and understanding of the pathogenic pathways in AMD in relation to systemic disorders are also highlighted.

引用

页码：140 / 153

页数：14

共 160 条

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