Facile 1,2-aryl migration of 2-halomethyl-2-(4'-hydroxyphenyl) ketals: A novel single step synthesis of 4-hydroxyphenylacetic acid & its derivatives.

被引：5

作者：

Kumar, A ^{[1
]}

Rane, RA ^{[1
]}

Ravindran, VK ^{[1
]}

Dike, SY ^{[1
]}

机构：

[1] ICI INDIA RES & TECHNOL CTR,THANA 400601,MAHARASHTRA,INDIA

来源：

SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 07期

关键词：

D O I：

10.1080/00397919708003348

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2-Aryl migration of 1-halomethyl-2-(4-hydroxyphenyl) ketals, obtained from 2-bromoethyl 4-hydroxyacetophenone, under mild basic conditions have been shown to give 4-hydroxyphenylacetic acidor its derivtives which are key intermediates in the preparation of Atenolol, a well known cardiac beta-blocker.

引用

页码：1133 / 1141

页数：9

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