Comparison between gadolinium-enhanced 2D T1-weighted gradient-echo and spin-echo sequences in the detection of active multiple sclerosis lesions on 3.0T MRI

被引:7
作者
Aymerich, F. X. [1 ,3 ]
Auger, C. [1 ]
Alcaide-Leon, P. [1 ]
Pareto, D. [1 ]
Huerga, E. [1 ]
Corral, J. F. [1 ]
Mitjana, R. [1 ]
Sastre-Garriga, J. [2 ]
Montalban, X. [2 ]
Rovira, A. [1 ]
机构
[1] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Dept Radiol IDI, MR Unit, P Vall dHebron 119-129, Barcelona 08035, Spain
[2] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Dept Neurol Neuroimmunol, Ctr Esclerosi Multiple Catalunya Cemcat, Barcelona, Spain
[3] Univ Politecn Catalunya Barcelona Tech UPC, Dept Automat Control ESAII, Barcelona, Spain
关键词
Magnetic resonance imaging; Brain; Multiple sclerosis; Contrast sensitivity; Lesion conspicuity; CLINICALLY ISOLATED SYNDROMES; BRAIN; CRITERIA; CONSPICUITY; DIAGNOSIS; MS;
D O I
10.1007/s00330-016-4503-3
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To compare the sensitivity of enhancing multiple sclerosis (MS) lesions in gadolinium-enhanced 2D T1-weighted gradient-echo (GRE) and spin-echo (SE) sequences, and to assess the influence of visual conspicuity and laterality on detection of these lesions. One hundred MS patients underwent 3.0T brain MRI including gadolinium-enhanced 2D T1-weighted GRE and SE sequences. The two sets of contrast-enhanced scans were evaluated in random fashion by three experienced readers. Lesion conspicuity was assessed by the image contrast ratio (CR) and contrast-to-noise ratio (CNR). The intracranial region was divided into four quadrants and the impact of lesion location on detection was assessed in each slice. Six hundred and seven gadolinium-enhancing MS lesions were identified. GRE images were more sensitive for lesion detection (0.828) than SE images (0.767). Lesions showed a higher CR in SE than in GRE images, whereas the CNR was higher in GRE than SE. Most misclassifications occurred in the right posterior quadrant. The gadolinium-enhanced 2D T1-weighted GRE sequence at 3.0T MRI enables detection of enhancing MS lesions with higher sensitivity and better lesion conspicuity than 2D T1-weighted SE. Hence, we propose the use of gadolinium-enhanced GRE sequences rather than SE sequences for routine scanning of MS patients at 3.0T. aEuro cent 2D SE and GRE sequences are useful for detecting active MS lesions. aEuro cent Which of these sequences is more sensitive at high field remains uncertain. aEuro cent GRE sequence showed better sensitivity for detecting active MS lesions than SE. aEuro cent We propose GRE sequence for detecting active MS lesions at 3.0T.
引用
收藏
页码:1361 / 1368
页数:8
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