pH-Responsive Dendritic Core-Multishell Nanocarriers

被引：44

作者：

Fleige, Emanuel ^{[1
]}

Achazi, Katharina ^{[1
]}

Schaletzki, Karolina ^{[1
]}

Triemer, Therese ^{[1
]}

Haag, Rainer ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

来源：

JOURNAL OF CONTROLLED RELEASE | 2014年 / 185卷

关键词：

Drug delivery; Nile red; Doxorubicin; Transport capacity; Dynamic light scattering; Real time cell analysis; POLYMER THERAPEUTICS; DRUG-DELIVERY; SHELL ARCHITECTURES; TUMOR; TRANSPORT; SYSTEMS;

D O I：

10.1016/j.jconrel.2014.04.019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper we describe novel pH-responsive core-multishell (CMS) nanocarrier (pH-CMS), obtained by introducing an aromatic imine linker between the shell and the core. At a pH of 5 and lower the used imine linker was rapidly cleaved as demonstrated by NMR studies. The CMS nanocarriers were loaded with the dye Nile red (NR) and the anticancer drug doxorubicin (DOX), respectively. The transport capacities were determined using UV/Vis spectroscopy, and the sizes of the loaded and unloaded CMS nanocarriers were investigated using dynamic light scattering (DLS). We could show that CMS nanocarriers efficiently transported NR in supramolecular aggregates, while DOX was transported in a unimolecular fashion. After cellular uptake the DOX-loaded pH-responsive nanocarriers showed higher toxicities than the stable CMS nanocarriers. This is due to a more efficient DOX release caused by the cleavage of the pH-labile imine bond at lower pH within the intracellular compartments. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：99 / 108

页数：10

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