Laccase from Basidiomycetous Fungus Catalyzes the Synthesis of Substituted 5-Deaza-10-oxaflavins via a Domino Reaction

被引：33

作者：

Kidwai, Mazaahir ^{[1
]}

Poddar, Roona ^{[1
]}

Diwaniyan, Sarika ^{[2
]}

Kuhad, Ramesh Chander ^{[2
]}

机构：

[1] Univ Delhi, Dept Chem, Green Res Lab, Delhi 110007, India

[2] Univ Delhi, Dept Microbiol, Lignocellulose Biotechnol Lab, New Delhi 110021, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 04期

关键词：

aqueous medium; 5-deaza-10-oxaflavins; domino reactions; laccase; tetrahydroxanthen-1-ones; SOLVENT-FREE CONDITIONS; CYATHUS-BULLERI; CONDENSATION; DERIVATIVES; INHIBITORS;

D O I：

10.1002/adsc.200800611

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The present investigation provides a simple and convenient route for the synthesis of substituted 5-deaza-10-oxaflavins owing to their importance as probable redox coenzymes. The reaction of alpha,beta-unsaturated derivatives of barbituric acid and di-medone with catechol or 1,4-hydroquinones was catalyzed using laccase in aqueous medium. Quinones, generated in situ by the oxidation of the corresponding catechol or 1,4-hydroquinones., underwent a domino reaction with chalcones to produce 5-deaza-10-oxaflavins and tetrahydroxanthen-1-ones.

引用

页码：589 / 595

页数：7

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