Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells

被引：49

作者：

Huang, Jie ^{[1
]}

Guo, Li ^{[2
]}

机构：

[1] Weifang Peoples Hosp, Dept Gen Surg, 151 Guangwen Rd, Weifang 261041, Peoples R China

[2] Weifang Med Coll, Affiliated Hosp, Dept Pharm, Weifang, Peoples R China

来源：

ONCOLOGY RESEARCH | 2017年 / 25卷 / 02期

关键词：

SOX9; Papillary thyroid cancer (PTC); Invasion; Epithelial mesenchymal transition (EMT); SIGNALING PATHWAY; DOWN-REGULATION; EXPRESSION; PROGRESSION; METASTASIS; CARCINOMA; GROWTH; GENES; BOX;

D O I：

10.3727/096504016X14732772150307

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sex-determining region Y (SRY)-box 9 (SOX9) is a member of the SOX transcription factor family. Increasing evidence has reported that SOX9 plays different roles in various types of malignancies. However, the role of SOX9 in papillary thyroid cancer (PTC) is still unclear. The aim of this study was to investigate the role of SOX9 in PTC. Our results showed that SOX9 was upregulated in PTC tissues and cell lines. In addition, knockdown of SOX9 significantly inhibited PTC proliferation, colony formation, migration, and invasion, as well as epithelial mesenchymal transition (EMT) phenotype in TPC-1 and BCPAP cells. Moreover, knockdown of SOX9 significantly inhibited the expression levels of P-catenin, cyclin D1, and c-Myc in PTC cells. In conclusion, this is the first report demonstrating that knockdown of SOX9 inhibited PTC cell proliferation, invasion, and the EMT process via suppressing Wnt/beta-catenin signaling pathway. Thus, SOX9 may act as a novel molecular target for the prevention and treatment of PTC.

引用

页码：167 / 176

页数：10

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