Scope extension validation protocol: inclusion of analytes and matrices in an LC-MS/MS sulfonamide residues method

被引：17

作者：

Hoff, Rodrigo Barcellos ^{[1
,2
]}

Barreto, Fabiano ^{[2
]}

Melo, Jessica ^{[2
]}

Martins, Magda Targa ^{[2
]}

Pizzolato, Tania Mara ^{[1
]}

Ruaro Peralba, Maria do Carmo ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Inst Quim, Porto Alegre, RS, Brazil

[2] Minist Agr Pecuaria & Abastecimento, Lab Nacl Agr LANAGRO RS, Porto Alegre, RS, Brazil

来源：

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT | 2014年 / 31卷 / 01期

关键词：

sulfonamides; tandem mass spectrometry; validation; residue analysis; scope extension; 2002/657/EC; BETA-LACTAM ANTIBIOTICS; LIQUID-CHROMATOGRAPHY; MILK; STRATEGIES; BRAZIL; EGGS;

D O I：

10.1080/19440049.2013.861082

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Validation is a required process for analytical methods. However, scope extension, i.e. inclusion of more analytes, other matrices and/or minor changes in extraction procedures, can be achieved without a full validation protocol, which requires time and is laborious to the laboratory. This paper presents a simple and rugged protocol for validation in the case of extension of scope. Based on a previously reported method for analysis of sulfonamide residues using LC-MS/MS, inclusion of more analytes, metabolites, matrices and optimisation for the extraction procedure are presented in detail. Initially, the method was applied only to liver samples. In this work, milk, eggs and feed were also added to the scope. Several case-specific validation protocols are proposed for extension of scope.

引用

页码：39 / 47

页数：9

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