Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

被引：59
|
作者：
Xin, Lijing [1 ]
Ipek, Ozlem [1 ]
Beaumont, Maurice [2 ]
Shevlyakova, Maya [2 ]
Christinat, Nicolas [3 ]
Masoodi, Mojgan [3 ]
Greenberg, Norman [4 ]
Gruetter, Rolf [1 ]
Cuenoud, Bernard [4 ]
机构：
[1] Ecole Polytech Fed Lausanne, Ctr Biomed Imaging, Lausanne, Switzerland
[2] Nestle Res Ctr, Clin Dev Unit, Lausanne, Switzerland
[3] Nestle Inst Hlth Sci SA, Lausanne, Switzerland
[4] Nestle Hlth Sci, Epalinges, Switzerland
来源：
FRONTIERS IN NUTRITION | 2018年 / 5卷
关键词：
ketones; NAD; brain energy metabolism; medium chain triglycerides; hydroxybutyrates; phosphorus magnetic resonance spectorscopy; nutritional sciences; MAGNETIC-RESONANCE-SPECTROSCOPY; METABOLITE CONCENTRATIONS; REDOX STATE; FATTY-ACIDS; ANTICONVULSANT; PROTON;
D O I：
10.3389/fnut.2018.00062
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD(+)/NADH ratio in the resting brain of healthy young adults. As NAD is an important energetic and signaling metabolic modulator, these results provide mechanistic clues on how nutritional ketosis might contribute to the preservation of brain health.
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页数：8
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