Genome-wide association study of panic disorder in the Japanese population

被引：83

作者：

Otowa, Takeshi ^{[2
]}

Yoshida, Eiji ^{[3
]}

Sugaya, Nagisa ^{[3
]}

Yasuda, Shin ^{[3
,4
]}

Nishimura, Yukika ^{[5
]}

Inoue, Ken ^{[6
]}

Tochigi, Mamoru ^{[2
]}

Umekage, Tadashi ^{[1
]}

Miyagawa, Taku ^{[7
]}

Nishida, Nao ^{[7
]}

Tokunaga, Katsushi ^{[7
]}

Tanii, Hisashi ^{[5
]}

Sasaki, Tsukasa ^{[1
]}

Kaiya, Hisanobu ^{[3
,4
]}

Okazaki, Yuji ^{[8
]}

机构：

[1] Univ Tokyo, Hlth Serv Ctr, Sect Mental Hlth, Tokyo 1138655, Japan

[2] Univ Tokyo, Dept Neuropsychiat, Grad Sch Med, Tokyo 1138655, Japan

[3] Akasaka Mental Clin, Outpatient Clin Anxiety Disorders, Tokyo, Japan

[4] Nagoya Mental Clin, Res Ctr Pan Disorder, Nagoya, Aichi, Japan

[5] Mie Univ, Dept Neuropsychiat, Grad Sch Med, Tsu, Mie 514, Japan

[6] Fujita Hlth Univ, Sch Med, Dept Publ Hlth, Aichi, Japan

[7] Univ Tokyo, Grad Sch Med, Dept Human Genet, Tokyo 1138655, Japan

[8] Tokyo Metropolitan Matsuzawa Hosp, Dept Neurol, Tokyo, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2009年 / 54卷 / 02期

关键词：

BRLMM; genome-wide association study; Japanese; panic disorder; 500K SNP chip; RECEPTOR GENE POLYMORPHISM; FREQUENCY; GENOTYPE; POWER;

D O I：

10.1038/jhg.2008.17

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety. Although a number of association studies have been conducted, no gene has been identified as a susceptibility locus. In this study, we conducted a genome-wide association study of PD in 200 Japanese patients and the same number of controls, using the GeneChip Human Mapping 500 K Array Set. Genotypes were determined using the Bayesian Robust Linear Model with Mahalanobis (BRLMM) genotype calling algorithm. The genotype data were data-cleaned using criteria for SNP call rate (>= 95%), Hardy-Weinberg equilibrium (P >= 0.1%) and minor allele frequency (>= 5%). The significance level of the allele P-value was set at 1.0 x 10(-6), to make false discovery rate (FDR) <0.05. As a result, seven SNPs were significantly associated with PD, which were located in or adjacent to genes including PKP1, PLEKHG1, TMEM16B, CALCOCO1, SDK2 and CLU (or APO-J). Studies with other samples are required to confirm the results.

引用

页码：122 / 126

页数：5

共 20 条

[1] A tutorial on statistical methods for population association studies [J].

Balding, David J. .

NATURE REVIEWS GENETICS, 2006, 7 (10) :781-791

[2] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[3] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[4] Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease [J].

Deckert, J ;

Nothen, MM ;

Franke, P ;

Delmo, C ;

Fritze, J ;

Knapp, M ;

Maier, W ;

Beckmann, H ;

Propping, P .

MOLECULAR PSYCHIATRY, 1998, 3 (01) :81-85

[5] Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder [J].

Deckert, J ;

Catalano, M ;

Syagailo, YV ;

Bosi, M ;

Okladnova, O ;

Di Bella, D ;

Nöthen, MM ;

Maffei, P ;

Franke, P ;

Fritze, J ;

Maier, W ;

Propping, P ;

Beckmann, H ;

Bellodi, L ;

Lesch, KP .

HUMAN MOLECULAR GENETICS, 1999, 8 (04) :621-624

[6]

EATON WW, 1994, AM J PSYCHIAT, V151, P413

[7] Transcriptional activities of cholecystokinin promoter haplotypes and their relevance to panic disorder susceptibility [J].

Ebihara, M ;

Ohba, H ;

Hattori, E ;

Yamada, K ;

Yoshikawa, T .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 118B (01) :32-35

[8] Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q [J].

Hamilton, SP ;

Fyer, AJ ;

Durner, M ;

Heiman, GA ;

de Leon, AB ;

Hodge, SE ;

Knowles, JA ;

Weissman, MM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2550-2555

[9] Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22 [J].

Hamilton, SP ;

Slager, SL ;

Heiman, GA ;

Deng, ZM ;

Haghighi, F ;

Klein, DF ;

Hodge, SE ;

Weissman, MM ;

Fyer, AJ ;

Knowles, JA .

BIOLOGICAL PSYCHIATRY, 2002, 51 (07) :591-601

[10] Association studies of the CT repeat polymorphism in the 5′ upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects [J].

Hattori, E ;

Yamada, K ;

Toyota, T ;

Yoshitsugu, K ;

Toru, M ;

Shibuya, H ;

Yoshikawa, T .

AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 105 (08) :779-782

← 1 2 →