Genome-wide association study of panic disorder in the Japanese population

被引：82

作者：

Otowa, Takeshi ^{[2
]}

Yoshida, Eiji ^{[3
]}

Sugaya, Nagisa ^{[3
]}

Yasuda, Shin ^{[3
,4
]}

Nishimura, Yukika ^{[5
]}

Inoue, Ken ^{[6
]}

Tochigi, Mamoru ^{[2
]}

Umekage, Tadashi ^{[1
]}

Miyagawa, Taku ^{[7
]}

Nishida, Nao ^{[7
]}

Tokunaga, Katsushi ^{[7
]}

Tanii, Hisashi ^{[5
]}

Sasaki, Tsukasa ^{[1
]}

Kaiya, Hisanobu ^{[3
,4
]}

Okazaki, Yuji ^{[8
]}

机构：

[1] Univ Tokyo, Hlth Serv Ctr, Sect Mental Hlth, Tokyo 1138655, Japan

[2] Univ Tokyo, Dept Neuropsychiat, Grad Sch Med, Tokyo 1138655, Japan

[3] Akasaka Mental Clin, Outpatient Clin Anxiety Disorders, Tokyo, Japan

[4] Nagoya Mental Clin, Res Ctr Pan Disorder, Nagoya, Aichi, Japan

[5] Mie Univ, Dept Neuropsychiat, Grad Sch Med, Tsu, Mie 514, Japan

[6] Fujita Hlth Univ, Sch Med, Dept Publ Hlth, Aichi, Japan

[7] Univ Tokyo, Grad Sch Med, Dept Human Genet, Tokyo 1138655, Japan

[8] Tokyo Metropolitan Matsuzawa Hosp, Dept Neurol, Tokyo, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2009年 / 54卷 / 02期

关键词：

BRLMM; genome-wide association study; Japanese; panic disorder; 500K SNP chip; RECEPTOR GENE POLYMORPHISM; FREQUENCY; GENOTYPE; POWER;

D O I：

10.1038/jhg.2008.17

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety. Although a number of association studies have been conducted, no gene has been identified as a susceptibility locus. In this study, we conducted a genome-wide association study of PD in 200 Japanese patients and the same number of controls, using the GeneChip Human Mapping 500 K Array Set. Genotypes were determined using the Bayesian Robust Linear Model with Mahalanobis (BRLMM) genotype calling algorithm. The genotype data were data-cleaned using criteria for SNP call rate (>= 95%), Hardy-Weinberg equilibrium (P >= 0.1%) and minor allele frequency (>= 5%). The significance level of the allele P-value was set at 1.0 x 10(-6), to make false discovery rate (FDR) <0.05. As a result, seven SNPs were significantly associated with PD, which were located in or adjacent to genes including PKP1, PLEKHG1, TMEM16B, CALCOCO1, SDK2 and CLU (or APO-J). Studies with other samples are required to confirm the results.

引用

页码：122 / 126

页数：5

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