Silica coating of the pore walls of a microporous polycaprolactone membrane to be used in bone tissue engineering

被引：13
作者：
Demirdogen, B. [1 ,2 ]
Plazas Bonilla, C. E. [3 ]
Trujillo, S. [4 ]
Perilla, J. E. [5 ]
Elcin, A. E. [1 ,2 ]
Elcin, Y. M. [1 ,2 ]
Gomez Ribelles, J. L. [4 ,6 ]
机构：
[1] Ankara Univ, Stem Cell Inst, TEBN Lab, TR-06100 Ankara, Turkey
[2] Ankara Univ, Dept Chem, Fac Sci, TEBN Lab, TR-06100 Ankara, Turkey
[3] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Proc Quim & Bioquim,Sede Bogota, Bogota 111321, Colombia
[4] Univ Politecn Valencia, Ctr Biomat & Tissue Engn, E-46022 Valencia, Spain
[5] Univ Nacl Colombia, Fac Ingn, Dept Ingn Quim & Ambiental, Grp Proc Quim & Bioquim,Sede Bogota, Bogota 111321, Colombia
[6] CIBER BBN, Valencia, Spain
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2014年 / 102卷 / 09期
关键词：
polycaprolactone-silica; hybrid composites; mesenchymal stem cells; osteogenic differentiation; silica coating; POLY(L-LACTIC ACID) SCAFFOLDS; SOL-GEL PROCESS; HYBRID COATINGS; IN-VITRO; BIOACTIVE GLASS; NANOCOMPOSITES; BIOMATERIALS; REGENERATION; DEGRADATION; PERFORMANCE;
D O I：
10.1002/jbm.a.34999
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Polycaprolactone/silica microporous hybrid membranes were produced in two steps: A microporous polycaprolactone membrane with an interconnected porosity of 80% was obtained via a freeze extraction procedure, then silica was formed by a sol-gel reaction inside the micropores using tetraethyl orthosilicate, TEOS, as silica precursor. It is shown that silica forms a thin coating layer homogeneously distributed over the pore walls when sol-gel reaction is catalyzed by hydrochloric acid, while it forms submicron spherical particles when using basic catalyzer. Some physical properties and the viability and osteoblastic differentiation of bone marrow rat mesenchymal stem cells cultured on pure and hybrid membranes were studied. (C) 2013 Wiley Periodicals, Inc.
引用
收藏
页码：3229 / 3236
页数：8
相关论文
共 38 条
  • [1] Biological performance of a polycaprolactone-based scaffold used as fusion cage device in a large animal model of spinal reconstructive surgery
    Abbah, Sunny A.
    Lam, Christopher X. L.
    Hutmacher, Dietmar W.
    Goh, James C. H.
    Wong, Hee-Kit
    [J]. BIOMATERIALS, 2009, 30 (28) : 5086 - 5093
  • [2] Influence of the macro and micro-porous structure on the mechanical behavior of poly(L-lactic acid) scaffolds
    Acosta Santamaria, V.
    Deplaine, H.
    Mariggio, D.
    Villanueva-Molines, A. R.
    Garcia-Aznar, J. M.
    Gomez Ribelles, J. L.
    Doblare, M.
    Gallego Ferrer, G.
    Ochoa, I.
    [J]. JOURNAL OF NON-CRYSTALLINE SOLIDS, 2012, 358 (23) : 3141 - 3149
  • [3] Synthesis and Electrospinning of ε-Polycaprolactone-Bioactive Glass Hybrid Biomaterials via a Sol-Gel Process
    Allo, Bedilu A.
    Rizkalla, Amin S.
    Mequanint, Kibret
    [J]. LANGMUIR, 2010, 26 (23) : 18340 - 18348
  • [4] [Anonymous], 1990, SOL GEL SCI
  • [5] Mesenchymal stem cells: clinical applications and biological characterization
    Barry, FP
    Murphy, JM
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2004, 36 (04) : 568 - 584
  • [6] Development and performance analysis of PCL/silica nanocomposites for bone regeneration
    Calandrelli, Luigi
    Annunziata, Marco
    Della Ragione, Fulvio
    Laurienzo, Paola
    Malinconico, Mario
    Oliva, Adriana
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2010, 21 (11) : 2923 - 2936
  • [7] Sol-gel synthesis, structure and bioactivity of polycaprolactone/CaO•SiO2 hybrid material
    Catauro, M
    Raucci, MG
    De Gaetano, F
    Buri, A
    Marotta, A
    Ambrosio, L
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2004, 15 (09) : 991 - 995
  • [8] Proteome Analysis of Rat Bone Marrow Mesenchymal Stem Cell Differentiation
    Celebi, Betul
    Elcin, A. Eser
    Elcin, Y. Murat
    [J]. JOURNAL OF PROTEOME RESEARCH, 2010, 9 (10) : 5217 - 5227
  • [9] In vitro bioactivity and degradation of polycaprolactone composites containing silicate fillers
    Chouzouri, Georgia
    Xanthos, Marino
    [J]. ACTA BIOMATERIALIA, 2007, 3 (05) : 745 - 756
  • [10] Biomimetic hydroxyapatite coating on pore walls improves osteointegration of poly(L-lactic acid) scaffolds
    Deplaine, H.
    Lebourg, M.
    Ripalda, P.
    Vidaurre, A.
    Sanz-Ramos, P.
    Mora, G.
    Prosper, F.
    Ochoa, I.
    Doblare, M.
    Gomez Ribelles, J. L.
    Izal-Azcarate, I.
    Gallego Ferrer, G.
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2013, 101B (01) : 173 - 186
1234