Outcome of Soft-tissue Reconstruction in the Setting of Combined Preoperative and Intraoperative Radiotherapy for Extremity Soft-tissue Sarcomas

被引：6

作者：

Honig, Rachel L. ^{[1
]}

Tibbo, Meagan E. ^{[1
]}

Mallett, Katherine E. ^{[1
]}

Bakri, Karim ^{[2
]}

Ahmed, Safia K. ^{[3
]}

Petersen, Ivy A. ^{[3
]}

Rose, Peter S. ^{[1
]}

Moran, Steven L. ^{[2
]}

Houdek, Matthew T. ^{[1
]}

机构：

[1] Mayo Clin, Dept Orthoped Surg, Rochester, MN USA

[2] Mayo Clin, Div Plast & Reconstruct Surg, Rochester, MN USA

[3] Mayo Clin, Dept Radiat Oncol, Rochester, MN USA

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 12期

关键词：

Intraoperative radiotherapy; IORT; limb salvage; soft-tissue reconstruction; flap; LIMB-SPARING SURGERY; RADIATION-THERAPY; FRACTURES;

D O I：

10.21873/anticanres.14718

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Reconstruction for soft-tissue sarcomas is complex and often uses soft-tissue flaps. To preserve critical structures, intraoperative radiotherapy (IORT) can be used to boost the total dose to these critical structures and close margins; however, there are limited data on the outcome of soft tissue reconstruction in patients treated with IORT. Patients and Methods: Twenty patients received IORT with soft-tissue flap coverage. There were 14 tumors of the lower extremities and six of the upper, including seven free-flaps and 13 pedicle flaps. Mean preoperative and IORT doses were 49.4 Gy and 10.4 Gy, respectively, with a mean total dose of 59.8 Gy. Results: Seven (35%) patients had a complication, most commonly an infection (n=4, 27%). Total flap loss occurred in one treated with pedicle flap. Four (20%) patients suffered a radiation-associated fracture. At the final follow-up, the mean Musculoskeletal Tumor Society Score was 75 +/- 11%. Conclusion: Complications and postoperative fractures were common with IORT, however, there were no cases requiring amputation.

引用

页码：6941 / 6945

页数：5

共 20 条

[1] POSITIVE SURGICAL MARGINS IN SOFT TISSUE SARCOMA TREATED WITH PREOPERATIVE RADIATION: IS A POSTOPERATIVE BOOST NECESSARY? [J].