The revolution of whole genome sequencing to study parasites

被引：18

作者：

Forrester, Sarah Jayne ^{[1
]}

Hall, Neil ^{[1
]}

机构：

[1] Univ Liverpool, Dept Comparat & Funct Genom, Liverpool L69 7ZB, Merseyside, England

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2014年 / 195卷 / 02期

基金：

英国医学研究理事会;

关键词：

Genome sequencing; Genome structure; Antigenic variation; Comparative genomics; Drug target; PLASMODIUM-FALCIPARUM; EXPRESSION SITES; ANTIGENIC VARIATION; TRYPANOSOMA-BRUCEI; TOXOPLASMA-GONDII; DRUG TARGETS; DRAFT GENOME; MALARIA; IDENTIFICATION; DIVERSITY;

D O I：

10.1016/j.molbiopara.2014.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome sequencing has revolutionized the way in which we approach biological research from fundamental molecular biology to ecology and epidemiology. In the last 10 years the field of genomics has changed enormously as technology has improved and the tools for genomic sequencing have moved out of a few dedicated centers and now can be performed on bench-top instruments. In this review we will cover some of the key discoveries that were catalyzed by some of the first genome projects and discuss how this field is developing, what the new challenges are and how this may impact on research in the near future. (C) 2014 Published by Elsevier B.V.

引用

页码：77 / 81

页数：5

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