DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network

被引:39
作者
Lin, Yuhong [1 ]
Jiang, Lili [1 ]
Huang, Yuqing [1 ]
Yang, Yuling [1 ]
He, Yu [1 ]
Lu, Chunhua [1 ]
Yang, Huanghao [1 ]
机构
[1] Fuzhou Univ, MOE Key Lab Analyt Sci Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Technol Food Sa, State Key Lab Photocatalysis Energy & Environm,Co, Fuzhou 350116, Fujian, Peoples R China
基金
中国国家自然科学基金;
关键词
CANCER-CELLS; EFFICIENT CAPTURE; RECOGNITION; PARTICLES; HYDROGEL; SIZE;
D O I
10.1039/c9cc02365h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
DNA-triggered reversible isolation and recovery of circulating tumor cells (CTCs) is presented based on a multivalent dual-specific aptamer-tethered rolling circle amplification (MA-RCA) network. The multivalent binding sites endow the MA-RCA network with a strong binding ability towards CTCs, and the repeated cell capture/release processes are also actualized in a noninvasive manner.
引用
收藏
页码:5387 / 5390
页数:4
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