Identifying specific receptors for cargo-mediated autophagy

被引：29

作者：

Goodall, Megan ^{[1
]}

Thorburn, Andrew ^{[1
]}

机构：

[1] Univ Colorado, Dept Pharmacol, Aurora, CO 80045 USA

来源：

CELL RESEARCH | 2014年 / 24卷 / 07期

关键词：

ANDROGEN RECEPTOR; COACTIVATOR; IRON;

D O I：

10.1038/cr.2014.56

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macroautophagy has been implicated in numerous diseases, yet our understanding of the proteins responsible for the turnover of specific cargo by autophagy is limited. In a recent paper published in Nature, Mancias et al. used quantitative proteomics to identify a cohort of autophagosome-enriched proteins, one of which, nuclear receptor coactivator 4 (NCOA4) was shown to be required for the selective delivery of ferritin to the lysosome, ultimately regulating intracellular iron by autophagic turnover of ferritin, or ferritinophagy.

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收藏

页码：783 / 784

页数：2

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