Dehydroepiandrosterone sulfate and cognition in midlife, post- menopausal women

被引：5

作者：

Chua, Charlene K. Z. ^{[1
]}

Henderson, Victor W. ^{[2
,3
]}

Dennerstein, Lorraine ^{[4
]}

Ames, David ^{[5
]}

Szoeke, Cassandra ^{[1
]}

机构：

[1] Univ Melbourne, Dept Med, Parkville, Vic 3052, Australia

[2] Stanford Univ, Dept Hlth Res & Policy Epidemiol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[4] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia

[5] Natl Ageing Res Inst, Parkville, Vic, Australia

来源：

NEUROBIOLOGY OF AGING | 2014年 / 35卷 / 07期

基金：

英国医学研究理事会;

关键词：

Cognition; Dehydroepiandrosterone sulfate; Menopause; Midlife; Women;

D O I：

10.1016/j.neurobiolaging.2014.01.140

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The association between serum dehydroepiandrosterone sulfate (DHEAS) and cognition was assessed in 218 healthy, midlife, post-menopausal women, aged 55-65 years. In cross-sectional analyses, DHEAS level was not significantly associated with a standardized score of global cognition or with individual test scores from a comprehensive neuropsychological battery (all p-values >0.05). In longitudinal analyses of 176 women, DHEAS level was unassociated with cognition 2 years later or with 2-year change in cognition. These findings fail to support the view that DHEAS is substantially related to cognitive function in midlife, post-menopausal women. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：1654 / 1655

页数：2

共 4 条

[1] [Anonymous], 1981, Steroid Hormone Regulation of the Brain
[2] MENOPAUSAL SYMPTOMS IN AUSTRALIAN WOMEN
DENNERSTEIN, L
SMITH, AMA
MORSE, C
BURGER, H
GREEN, A
HOPPER, J
RYAN, M
[J]. MEDICAL JOURNAL OF AUSTRALIA, 1993, 159 (04) : 232 - 236
[3] Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)
Maninger, Nicole
Wolkowitz, Owen M.
Reus, Victor I.
Epel, Elissa S.
Mellon, Synthia H.
[J]. FRONTIERS IN NEUROENDOCRINOLOGY, 2009, 30 (01) : 65 - 91
[4] Valenti G, 2009, J ENDOCRINOL INVEST, V32, P766, DOI [10.1007/BF03346534, 10.3275/6438]

← 1 →