Mucin-type O-glycans and leukosialin

被引：55
作者：
Fukuda, M [1 ]
Tsuboi, ST [1 ]
机构：
[1] Burnham Inst, Canc Res Ctr, Glycobiol Program, La Jolla, CA 92037 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1999年 / 1455卷 / 2-3期
关键词：
mucin-type O-glycan; core; 2; branch; core 2 branching beta 1,6-N-acetylglucosaminyltransferase; cell adhesion;
D O I：
10.1016/S0925-4439(99)00067-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mucin-type O-glycans on leukocytes acquire functions once they contain core 2 branches, which can be synthesized by core 2 beta 1,6-N-acetylglucosaminyltransferase (C2GnT). Recently, understanding the roles of mucin-type O-glycans has been significantly advanced by generating transgenic mice overexpressing C2GnT or knockout mice defective in C2GnT. This review article summarizes previous results implicating the roles of mucin-type O-glycans and the most recent studies to test such a hypothesis. These results, taken together, demonstrate that mucin-type O-glycans either facilitate or attenuate cell adhesion depending on the structures of non-reducing termini. (C) 1999 Elsevier Science B.V. All rights reserved.
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收藏
页码：205 / 217
页数：13
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