Targeted Bioimaging and Photodynamic Therapy Nanoplatform Using an Aptamer-Guided G-Quadruplex DNA Carrier and Near-Infrared Light

被引：178

作者：

Yuan, Quan ^{[1
,2
,3
]}

Wu, Yuan ^{[1
,2
]}

Wang, Jie ^{[3
]}

Lu, Danqing ^{[1
,2
]}

Zhao, Zilong ^{[1
,2
]}

Liu, Tao ^{[1
,2
]}

Zhang, Xiaobing ^{[1
,2
]}

Tan, Weihong ^{[1
,2
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Mol Sci & Biomed Lab,Coll Biol, Changsha 410082, Hunan, Peoples R China

[2] Hunan Univ, Collaborat Res Ctr Chem & Mol Med, Changsha 410082, Hunan, Peoples R China

[3] Wuhan Univ, Coll Chem & Mol Sci, Minist Educ, Key Lab Analyt Chem Biol & Med, Wuhan 430072, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 52期

基金：

中国国家自然科学基金;

关键词：

aptamer; G-quadruplexes; imaging agents; nanoparticles; singlet oxygen; UP-CONVERSION NANOCRYSTALS; CELLS; NANOPARTICLES; CONJUGATE; BINDING;

D O I：

10.1002/anie.201305707

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Target practice: A novel photodynamic therapy system has been constructed by taking advantage of the specific molecular recognition of an aptamer, loading capability of a G-quadruplex, and upconversion of nanoparticles using near-infrared (NIR) light. This system selectively delivers a photosensitizer to targeted cells and upon irradiation with NIR light demonstrates phototoxicity effects. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：13965 / 13969

页数：5

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