Targeted Bioimaging and Photodynamic Therapy Nanoplatform Using an Aptamer-Guided G-Quadruplex DNA Carrier and Near-Infrared Light

被引：178
作者：
Yuan, Quan [1 ,2 ,3 ]
Wu, Yuan [1 ,2 ]
Wang, Jie [3 ]
Lu, Danqing [1 ,2 ]
Zhao, Zilong [1 ,2 ]
Liu, Tao [1 ,2 ]
Zhang, Xiaobing [1 ,2 ]
Tan, Weihong [1 ,2 ]
机构：
[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Mol Sci & Biomed Lab,Coll Biol, Changsha 410082, Hunan, Peoples R China
[2] Hunan Univ, Collaborat Res Ctr Chem & Mol Med, Changsha 410082, Hunan, Peoples R China
[3] Wuhan Univ, Coll Chem & Mol Sci, Minist Educ, Key Lab Analyt Chem Biol & Med, Wuhan 430072, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 52期
基金：
中国国家自然科学基金;
关键词：
aptamer; G-quadruplexes; imaging agents; nanoparticles; singlet oxygen; UP-CONVERSION NANOCRYSTALS; CELLS; NANOPARTICLES; CONJUGATE; BINDING;
D O I：
10.1002/anie.201305707
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Target practice: A novel photodynamic therapy system has been constructed by taking advantage of the specific molecular recognition of an aptamer, loading capability of a G-quadruplex, and upconversion of nanoparticles using near-infrared (NIR) light. This system selectively delivers a photosensitizer to targeted cells and upon irradiation with NIR light demonstrates phototoxicity effects. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：13965 / 13969
页数：5
相关论文
共 39 条
[1]   Targeted Indocyanine-Green-Loaded Calcium Phosphosilicate Nanoparticles for In Vivo Photodynamic Therapy of Leukemia [J].
Barth, Brian M. ;
Altinoglu, Erhan I. ;
Shanmugavelandy, Sriram S. ;
Kaiser, James M. ;
Crespo-Gonzalez, Daniza ;
DiVittore, Nicole A. ;
McGovern, Christopher ;
Goff, Trevor M. ;
Keasey, Nicole R. ;
Adair, James H. ;
Loughran, Thomas P., Jr. ;
Claxton, David F. ;
Kester, Mark .
ACS NANO, 2011, 5 (07) :5325-5337
[2]   Quadruplex DNA: sequence, topology and structure [J].
Burge, Sarah ;
Parkinson, Gary N. ;
Hazel, Pascale ;
Todd, Alan K. ;
Neidle, Stephen .
NUCLEIC ACIDS RESEARCH, 2006, 34 (19) :5402-5415
[3]   Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization [J].
Celli, Jonathan P. ;
Spring, Bryan Q. ;
Rizvi, Imran ;
Evans, Conor L. ;
Samkoe, Kimberley S. ;
Verma, Sarika ;
Pogue, Brian W. ;
Hasan, Tayyaba .
CHEMICAL REVIEWS, 2010, 110 (05) :2795-2838
[4]   Facile Preparation of Multifunctional Upconversion Nanoprobes for Multimodal Imaging and Dual-Targeted Photothermal Therapy [J].
Cheng, Liang ;
Yang, Kai ;
Li, Yonggang ;
Chen, Jianhua ;
Wang, Chao ;
Shao, Mingwang ;
Lee, Shuit-Tong ;
Liu, Zhuang .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (32) :7385-7390
[5]   Specific DNA G-Quadruplexes Bind to Ethanolamines [J].
Cheng, Xiaohong ;
Liu, Xiangjun ;
Bing, Tao ;
Zhao, Rui ;
Xiong, Shaoxiang ;
Shangguan, Dihua .
BIOPOLYMERS, 2009, 91 (10) :874-883
[6]   Selective antitumor effect of novel protease-mediated photodynamic agent [J].
Choi, Yongdoo ;
Weissleder, Ralph ;
Tung, Ching-Hsuan .
CANCER RESEARCH, 2006, 66 (14) :7225-7229
[7]   Biophysical and biological properties of quadruplex oligodeoxyribonucleotides [J].
Dapic, V ;
Abdomerovic, V ;
Marrington, R ;
Peberdy, J ;
Rodger, A ;
Trent, JO ;
Bates, PJ .
NUCLEIC ACIDS RESEARCH, 2003, 31 (08) :2097-2107
[8]   Targeting telomeres and telomerase [J].
De Cian, Anne ;
Lacroix, Laurent ;
Douarre, Celine ;
Temime-Smaali, Nassima ;
Trentesaux, Chantal ;
Riou, Jean-Francois ;
Mergny, Jean-Louis .
BIOCHIMIE, 2008, 90 (01) :131-155
[9]   "Fitting" Makes "Sensing" Simple: Label-Free Detection Strategies Based on Nucleic Acid Aptamers [J].
Du, Yan ;
Li, Bingling ;
Wang, Erkang .
ACCOUNTS OF CHEMICAL RESEARCH, 2013, 46 (02) :203-213
[10]   Preferential binding of a G-quadruplex ligand to human chromosome ends [J].
Granotier, C ;
Pennarun, G ;
Riou, L ;
Hoffschir, F ;
Gauthier, LR ;
De Cian, A ;
Gomez, D ;
Mandine, E ;
Riou, JF ;
Mergny, JL ;
Mailliet, P ;
Dutrillaux, B ;
Boussin, FD .
NUCLEIC ACIDS RESEARCH, 2005, 33 (13) :4182-4190
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