Use of artemisinin and its derivatives to treat HPV-infected/transformed cells and cervical cancer: a review

被引：2

作者：

Goodrich, Sarah K. ^{[1
]}

Schlegel, C. Richard ^{[2
]}

Wang, Guixang ^{[3
]}

Belinson, Jerome L. ^{[1
,3
]}

机构：

[1] Cleveland Clin, Div Gynecol Oncol, Cleveland, OH 44195 USA

[2] Georgetown Univ, Dept Pathol, Washington, DC 20057 USA

[3] Prevent Oncol Int, Cleveland Hts, OH USA

来源：

FUTURE ONCOLOGY | 2014年 / 10卷 / 04期

关键词：

artemisinin; cancer; cervix; DHA; dysplasia; HUMAN-PAPILLOMAVIRUS; INTRAEPITHELIAL NEOPLASIA; NATURAL-HISTORY; IN-VITRO; ANTIMALARIAL; ARTESUNATE; WOMEN; GROWTH; EPIDEMIOLOGY; ANGIOGENESIS;

D O I：

10.2217/FON.13.228

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cervical cancer and HPV-related diseases remain a burden in the developing world. While much progress has been gained in the detection of HPV and preneoplastic cervical lesions, the rate-limiting step in the prevention of cervical cancer is management of these women. A natural compound, artemisinin, and its derivatives appear to hold promise as a simple means of treatment. Laboratory studies have shown that this compound, and its derivatives, have activity against HPV-infected and -transformed cells and cervical cancer cells. In situations of compassionate use, studies have also demonstrated efficacy in clinical situations. Well-designed clinical trials relating to its use should be undertaken.

引用

页码：647 / 654

页数：8