Impact of lymphocytic thyroiditis on incidence of pathological incidental thyroid carcinoma

被引：15

作者：

Farrell, Eric ^{[1
]}

Heffron, Cynthia ^{[2
]}

Murphy, Matthew ^{[3
]}

O'Leary, Gerard ^{[4
]}

Sheahan, Patrick ^{[4
]}

机构：

[1] Univ Coll Cork, Sch Med, Cork, Ireland

[2] Cork Univ Hosp, Dept Pathol, Cork, Ireland

[3] South Infirm Victoria Univ Hosp, Dept Endocrinol, Cork, Cork, Ireland

[4] South Infirm Victoria Univ Hosp, Dept Otolaryngol Head & Neck Surg, Old Blackrock Rd, Cork, Cork, Ireland

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 01期

关键词：

thyroid cancer; Hashimoto's thyroiditis; Graves' disease; papillary carcinoma; lymphocytic thyroiditis; HASHIMOTOS-THYROIDITIS; PAPILLARY CARCINOMA; SYSTEMATIC AUTOPSY; CANCER; RISK; ASSOCIATION; DISEASE; THYROTROPIN; NODULES; SERIES;

D O I：

10.1002/hed.24544

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. The purpose of this study was to investigate the impact of lymphocytic thyroiditis on incidence of incidental thyroid cancers. Methods. We conducted a retrospective review of 713 consecutive patients who underwent thyroidectomies. Incidental thyroid cancer was defined as an unexpected cancer discovered on pathological examination outside the index nodule undergoing preoperative cytology. Results. We excluded 65 cases because of preoperative diagnosis of thyroid cancer, and 68 because of nonincidental cancer within the index nodule. Among the remaining 580 cases, there were 43 cases (7.4%) of incidental thyroid cancers. Incidental thyroid cancers were significantly associated with moderate/severe lymphocytic thyroiditis (relative risk=2.5; p=.03). Sixteen of 56 patients with moderate/severe lymphocytic thyroiditis had Graves' disease, none of whom had incidental thyroid cancer. The risk of incidental thyroid cancer associated with moderate/severe lymphocytic thyroiditis was significantly higher in nonGraves' than patients with Graves' disease (p=.05). Conclusion. The risk of incidental thyroid cancer is significantly increased in patients with moderate/severe lymphocytic thyroiditis. Moderate/severe lymphocytic thyroiditis associated with Graves' disease seems to have a lower risk of incidental thyroid cancer. (C) 2016 Wiley Periodicals, Inc.

引用

页码：122 / 127

页数：6

共 31 条

[1] Hashimoto's Thyroiditis Is Not Associated with Increased Risk of Thyroid Cancer in Patients with Thyroid Nodules: A Single-Center Prospective Study [J].