A new triterpenoid saponin from Clinopodium chinense (Benth.) O. Kuntze

被引：11
作者：
Zeng, Biao [1 ,2 ]
Liu, Guang-Da [1 ]
Zhang, Bao-Bao [1 ]
Wang, Shan-shan [1 ]
Ma, Rui [1 ]
Zhong, Bei-Shan [1 ]
He, Bai-qiu [1 ]
Liang, Yan [3 ]
Wu, Fei-Hua [1 ]
机构：
[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing, Jiangsu, Peoples R China
[2] Guangzhou Baiyun Shan Ming Xing Pharmaceut Co Ltd, Guangzhou, Guangdong, Peoples R China
[3] Nanjing Sanhome Pharmaceut Co Ltd, Nanjing, Jiangsu, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Clinopodium chinense (Benth) O. Kuntze; triterpene saponin; platelet aggregation; thrombin time;
D O I：
10.1080/14786419.2015.1095745
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new triterpene saponin, 3,16,23,28,30-pentahydroxyl-olean-11,13(18)-dien-3-yl-[-d-glucopyranosyl-(12)]-[-d-glucopyranosyl-(13)]--d-fucopyranoside, was named Clinoposaponin D (1), together with six known triterpene saponins, buddlejasaponin IVb (2), buddlejasaponin IVa (3), buddlejasaponin IV (4), clinopodisides D (5), 11,16,23,28-Tetrahydroxyolean-12-en-3-yl-[-d-glucopyranosyl-(12)]-[-d-glucopyranosyl-(13)]--d-fucopyranoside (6) and prosaikogenin A (7), and two known triterpenes, saikogenin A (8) and saikogenin F (9) were isolated from Clinopodium chinense (Benth.) O. Kuntze. Their structures were elucidated on the basis of 1D, 2D NMR and MS analysis. Meanwhile, the effects of all compounds on rabbit platelet aggregation and thrombin time (TT) were investigated in vitro. Compounds 4 and 7 had significant promoting effects on platelet aggregation with EC50 value at 53.4 and 12.2M, respectively. In addition, the highest concentration (200M) of compounds 2 and 9 shortened TT by 20.6 and 25.1%, respectively.
引用
收藏
页码：1001 / 1008
页数：8
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