Pimarane diterpene from Viguiera arenaria (Asteraceae) inhibit rat carotid contraction

被引：28

作者：

Ambrosio, SR

Tirapelli, CR

Bonaventura, D

De Oliveira, AM

Da Costa, FB

机构：

[1] Univ Sao Paulo, Lab Farmacognosia, Fac Ciencias Farmaceut Ribeirao, BR-14040903 Ribeirao Preto, Brazil

[2] USP, Fac Filosofia Ciencias & Letras Ribeirao Pret, Dept Quim, Ribeirao Preto, Brazil

[3] USP, Fac Med Ribeirao Preto, Dept Farmacol, Ribeirao Preto, Brazil

[4] USP, Farmacol Lab, Fac Ciencias Farmaceut Ribeirao, Ribeirao Preto, Brazil

来源：

FITOTERAPIA | 2002年 / 73卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

Asteraceae; pimaranes; rat carotid; inhibitory effect;

D O I：

10.1016/S0367-326X(02)00170-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

ent-Pimara-8(14),15-dien-19-oic acid (PA) isolated from Viguiera arenaria (Asteraceae; Heliantheae) inhibited rat carotid rings contraction induced by phenylephrine (10(-8) mol/l) or potassium chloride (45 mmol/l) at concentration ranging from 5 to 20 mug/ml. This inhibitory effect was not reversible after the removal of this compound from the medium bath. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：484 / 489

页数：6

共 11 条

[1] CALCIUM CHANNELS IN MUSCLE-CELLS ISOLATED FROM RAT MESENTERIC-ARTERIES - MODULATION BY DIHYDROPYRIDINE DRUGS [J].