Stroke prevention in the young child with sickle cell anaemia

被引：2

作者：

Roberts, Lara ^{[1
]}

O'Driscoll, Sandra ^{[1
]}

Dick, Moira C. ^{[1
]}

Height, Sue E. ^{[1
]}

Deane, Colin ^{[2
]}

Goss, David E. ^{[2
]}

Pohl, Keith ^{[3
]}

Rees, David C. ^{[1
]}

机构：

[1] Kings Coll Hosp London, Dept Paediat Haematol, London SE5 9RS, England

[2] Kings Coll Hosp London, Vasc Lab, London SE5 9RS, England

[3] Evelina Childrens Hosp, Dept Paediat Neurol, London, England

来源：

ANNALS OF HEMATOLOGY | 2009年 / 88卷 / 10期

关键词：

Sickle cell anaemia; Transcranial Doppler; Stroke; Cerebrovascular accident; Children; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; DISEASE; RISK; SIBLINGS;

D O I：

10.1007/s00277-009-0757-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cerebrovascular disease resulting in stroke is a serious and preventable complication of sickle cell anaemia (SCA). Children at high risk of preventable stroke can be identified by transcranial Doppler ultrasound (TCD). Current guidelines in the UK recommend annual TCD screening from 3 years, although studies suggest an earlier peak incidence, between 2 and 5 years. A single centre retrospective review was undertaken to identify the prevalence of stroke and success of TCD screening in young children. We report five episodes of stroke in under 3s and outcome of TCD screening in children under 3, compared to over 3. TCD analysis was as successful in the 2-3-year age group as in the 3-4-year group. We therefore propose that all children with SCA should be offered TCD screening from the age of 2 years. Furthermore, infants with high risk features of SCA should undergo a first attempt at TCD screening even earlier.

引用

页码：943 / 946

页数：4

共 14 条

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[13]

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[14] A simple index using age, hemoglobin, and aspartate transaminase predicts increased intracerebral blood velocity as measured by transcranial Doppler scanning in children with sickle cell anemia [J].

Rees, David C. ;

Dick, Moira C. ;

Height, Sue E. ;

O'Driscoll, Sandra ;

Pohl, Keith R. E. ;

Goss, David E. ;

Deane, Colin R. .

PEDIATRICS, 2008, 121 (06) :E1628-E1632

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