Adaptive trial designs: what are multiarm, multistage trials?

被引：21
作者：
Millen, Gerard Cathal [1 ]
Yap, Christina [2 ,3 ]
机构：
[1] Birmingham Womens & Childrens NHS Fdn Trust, Paediat Oncol, Birmingham B4 6NH, W Midlands, England
[2] Univ Birmingham, Coll Med & Dent Sci, Inst Canc & Genom Sci, Canc Res UK Clin Trials Unit, Birmingham, W Midlands, England
[3] Inst Canc Res, Clin Trials & Stat Unit, London, England
来源：
ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION | 2020年 / 105卷 / 06期
关键词：
D O I：
10.1136/archdischild-2019-317826
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
引用
收藏
页码：376 / 378
页数：3
相关论文
共 10 条
  • [1] How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design - a reanalysis of 4 trials
    Barthel, F. M-S
    Parmar, M. K. B.
    Royston, P.
    [J]. TRIALS, 2009, 10
  • [2] Design and monitoring of multi-arm multi-stage clinical trials
    Ghosh, Pranab
    Liu, Lingyun
    Senchaudhuri, P.
    Gao, Ping
    Mehta, Cyrus
    [J]. BIOMETRICS, 2017, 73 (04) : 1289 - 1299
  • [3] Kim S, 2018, Int J Tuberc Lung Dis, V22, P34, DOI 10.5588/ijtld.17.0358
  • [4] Comparison of multi-arm multi-stage design and adaptive randomization in platform clinical trials
    Lin, Jianchang
    Bunn, Veronica
    [J]. CONTEMPORARY CLINICAL TRIALS, 2017, 54 : 48 - 59
  • [5] Comparison of anticipated and actual control group outcomes in randomised trials in paediatric oncology provides evidence that historically controlled studies are biased in favour of the novel treatment
    Moroz, Veronica
    Wilson, Jayne S.
    Kearns, Pamela
    Wheatley, Keith
    [J]. TRIALS, 2014, 15
  • [6] PALLMANN P, 2018, BMC MED, V16
  • [7] Novel designs for multi-arm clinical trials with survival outcomes with an application in ovarian cancer
    Royston, P
    Parmar, MKB
    Qian, W
    [J]. STATISTICS IN MEDICINE, 2003, 22 (14) : 2239 - 2256
  • [8] This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols
    Schiavone, Francesca
    Bathia, Riya
    Letchemanan, Krishna
    Masters, Lindsey
    Amos, Claire
    Bara, Anna
    Brown, Louise
    Gilson, Clare
    Pugh, Cheryl
    Atako, Nafisah
    Hudson, Fleur
    Parmar, Mahesh
    Langley, Ruth
    Kaplan, Richard S.
    Parker, Chris
    Attard, Gert
    Clarke, Noel W.
    Gillessen, Silke
    James, Nicholas D.
    Maughan, Tim
    Sydes, Matthew R.
    [J]. TRIALS, 2019, 20 (1)
  • [9] When to keep it simple - adaptive designs are not always useful
    Wason, James M. S.
    Brocklehurst, Peter
    Yap, Christina
    [J]. BMC MEDICINE, 2019, 17 (1)
  • [10] Wong CH, 2019, BIOSTATISTICS, V20, P273, DOI 10.1093/biostatistics/kxx069
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