A longitudinal study of anxiety and cognitive decline in dementia with Lewy bodies and Alzheimer's disease

被引：41

作者：

Breitve, Monica H. ^{[1
,2
,3
]}

Hynninen, Minna J. ^{[4
,5
]}

Bronnick, Kolbjorn ^{[6
,12
]}

Chwiszczuk, Luiza J. ^{[1
,3
,7
]}

Auestad, Bjorn H. ^{[8
,9
]}

Aarsland, Dag ^{[10
,11
]}

Rongve, Arvid ^{[1
,2
,3
]}

机构：

[1] Helse Fonna HF Haugesund Hosp, Dept Res & Innovat, Postbox 2170, N-5504 Haugesund, Norway

[2] Helse Fonna HF Haugesund Hosp, Psychiat Clin, Old Age Dept, Postbox 2170, N-5504 Haugesund, Norway

[3] Univ Bergen, Fac Med, Postbox 7804, N-5020 Bergen, Norway

[4] Univ Bergen, Dept Clin Psychol, Christies Gate 12, N-5015 Bergen, Norway

[5] NKS Olaviken Psychogeriatr Hosp, Ulriksdal 8, N-5009 Bergen, Norway

[6] Stavanger Univ Hosp, TIPS Ctr Clin Res Psychosis, N-4011 Stavanger, Norway

[7] Helse Fonna HF Haugesund Hosp, Dept Neurol, Med Clin, Postbox 2170, N-5504 Haugesund, Norway

[8] Stavanger Univ Hosp, Res Dept, Stavanger, Norway

[9] Univ Stavanger, Dept Math & Nat Sci, N-4011 Stavanger, Norway

[10] Stavanger Univ Hosp, Ctr Age Related Med, Armauer Hansensvei 20, N-4011 Stavanger, Norway

[11] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Div Neurogeriatr, S-14157 Huddinge, Sweden

[12] Univ Stavanger, Network Med Sci, N-4036 Stavanger, Norway

来源：

ALZHEIMERS RESEARCH & THERAPY | 2016年 / 8卷

关键词：

Alzheimer's disease; Dementia with Lewy bodies; Dementia; Anxiety; BPSD; Longitudinal; NEUROPSYCHIATRIC INVENTORY; PSYCHOLOGICAL SYMPTOMS; OLDER-ADULTS; IMPAIRMENT; DEPRESSION; FREQUENCY; ASSOCIATION; DIAGNOSIS; SEVERITY; HEALTH;

D O I：

10.1186/s13195-016-0171-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Anxiety in dementia is common but not well studied. We studied the associations of anxiety longitudinally in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Methods: In total, 194 patients with a first-time diagnosis of dementia were included (n = 122 patients with AD, n = 72 patients with DLB). Caregivers rated the patients' anxiety using the Neuropsychiatric Inventory, and self-reported anxiety was assessed with the anxiety and tension items on the Montgomery-Asberg Depression Rating Scale. The Mini Mental State Examination was used to assess cognitive outcome, and the Clinical Dementia Rating (CDR)-Global and CDR boxes were used for dementia severity. Linear mixed effects models were used for longitudinal analysis. Results: Neither in the total sample nor in AD or DLB was caregiver-rated anxiety significantly associated with cognitive decline or dementia severity over a 4-year period. However, in patients with DLB, self-reported anxiety was associated with a slower cognitive decline than in patients with AD. No support was found for patients with DLB with clinical anxiety having a faster decline than patients with DLB without clinical anxiety. Over the course of 4 years, the level of anxiety declined in DLB and increased in AD. Conclusions: Anxiety does not seem to be an important factor for the rate of cognitive decline or dementia severity over time in patients with a first-time diagnosis of dementia. Further research into anxiety in dementia is needed.

引用

页数：6

共 39 条

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