Meroterpenoids with BACE1 Inhibitory Activity from the Fruiting Body of Boletinus asiaticus

被引：15

作者：

Yatsu, Genki ^{[1
]}

Kino, Yoshihiro ^{[2
]}

Sasaki, Hiroaki ^{[3
]}

Satoh, Jun-ichi ^{[2
]}

Kinoshita, Kaoru ^{[1
]}

Koyama, Kiyotaka ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Dept Pharmacognosy & Phytochem, Noshio 2-522-1, Kiyose, Tokyo 2048588, Japan

[2] Meiji Pharmaceut Univ, Dept Bioinformat & Mol Neuropathol, 2-522-1 Noshio, Kiyose, Tokyo 2048588, Japan

[3] Shujitsu Univ, Sch Pharm, Naka Ku, Nishigawara 1-6-1, Okayama, Okayama 7038516, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 07期

关键词：

ALZHEIMERS-DISEASE;

D O I：

10.1021/acs.jnatprod.8b01092

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

BACE1 inhibitory activity-guided fractionation of an extract of the fruiting body of Boletinus asiaticus yielded five novel meroterpenoids (1-5) and one known compound (6; asiaticusin A). The structures of these compounds were determined by interpretation of NMR, MS, and IR spectral data. The five new compounds contain 4-hydroxybenzoic acid and geranylgeranoic acid units. Compounds 4-6 possessed BACE1 inhibitory activity (IC50 values: 14.7, 11.4, and 2.0 mu M, respectively).

引用

页码：1797 / 1801

页数：5

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