Meroterpenoids with BACE1 Inhibitory Activity from the Fruiting Body of Boletinus asiaticus

被引:14
作者
Yatsu, Genki [1 ]
Kino, Yoshihiro [2 ]
Sasaki, Hiroaki [3 ]
Satoh, Jun-ichi [2 ]
Kinoshita, Kaoru [1 ]
Koyama, Kiyotaka [1 ]
机构
[1] Meiji Pharmaceut Univ, Dept Pharmacognosy & Phytochem, Noshio 2-522-1, Kiyose, Tokyo 2048588, Japan
[2] Meiji Pharmaceut Univ, Dept Bioinformat & Mol Neuropathol, 2-522-1 Noshio, Kiyose, Tokyo 2048588, Japan
[3] Shujitsu Univ, Sch Pharm, Naka Ku, Nishigawara 1-6-1, Okayama, Okayama 7038516, Japan
来源
JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 07期
关键词
ALZHEIMERS-DISEASE;
D O I
10.1021/acs.jnatprod.8b01092
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
BACE1 inhibitory activity-guided fractionation of an extract of the fruiting body of Boletinus asiaticus yielded five novel meroterpenoids (1-5) and one known compound (6; asiaticusin A). The structures of these compounds were determined by interpretation of NMR, MS, and IR spectral data. The five new compounds contain 4-hydroxybenzoic acid and geranylgeranoic acid units. Compounds 4-6 possessed BACE1 inhibitory activity (IC50 values: 14.7, 11.4, and 2.0 mu M, respectively).
引用
收藏
页码:1797 / 1801
页数:5
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