A versatile method for the preparation of 2,2-disubstituted morpholine analogues

被引：19

作者：

Takemoto, T ^{[1
]}

Iio, Y ^{[1
]}

Nishi, T ^{[1
]}

机构：

[1] Sankyo Co Ltd, Med Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(00)00016-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a versatile synthetic method for the preparation of 2,2-disubstituted morpholine analogues. Iodoetherification of 1,1-disubstituted olefin with N-Boc-aminoethanol using NIS proceeded smoothly in a regioselective manner and the following cyclization was accomplished in good yield. We successfully applied this method for the preparation of the key intermediate 2 of tachykinin receptor antagonist. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1785 / 1788

页数：4

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