Parkin function in Parkinson's disease

被引:63
作者
Arkinson, Connor [1 ]
Walden, Helen [1 ]
机构
[1] Univ Glasgow, Inst Mol Cell & Syst Biol, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland
基金
英国医学研究理事会;
关键词
LIGASE PARKIN; ACTIVATION; REVEALS; MECHANISM; BINDING; DOMAIN; PRIMES;
D O I
10.1126/science.aar6606
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
[No abstract available]
引用
收藏
页码:267 / 268
页数:2
相关论文
共 15 条
[1]   Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation [J].
Aguirre, Jacob D. ;
Dunkerley, Karen M. ;
Mercier, Pascal ;
Shaw, Gary S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (02) :298-303
[2]   Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin [J].
Caulfield, Thomas R. ;
Fiesel, Fabienne C. ;
Moussaud-Lamodiere, Elisabeth L. ;
Dourado, Daniel F. A. R. ;
Flores, Samuel C. ;
Springer, Wolfdieter .
PLOS COMPUTATIONAL BIOLOGY, 2014, 10 (11)
[3]   Autoregulation of Parkin activity through its ubiquitin-like domain [J].
Chaugule, Viduth K. ;
Burchell, Lynn ;
Barber, Kathryn R. ;
Sidhu, Ateesh ;
Leslie, Simon J. ;
Shaw, Gary S. ;
Walden, Helen .
EMBO JOURNAL, 2011, 30 (14) :2853-2867
[4]   RING-Between-RING E3 Ligases: Emerging Themes amid the Variations [J].
Dove, Katja K. ;
Klevit, Rachel E. .
JOURNAL OF MOLECULAR BIOLOGY, 2017, 429 (22) :3363-3375
[5]   Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation [J].
Kazlauskaite, Agne ;
Martinez-Torres, R. Julio ;
Wilkie, Scott ;
Kumar, Atul ;
Peltier, Julien ;
Gonzalez, Alba ;
Johnson, Clare ;
Zhang, Jinwei ;
Hope, Anthony G. ;
Peggie, Mark ;
Trost, Matthias ;
van Aalten, Daan M. F. ;
Alessi, Dario R. ;
Prescott, Alan R. ;
Knebel, Axel ;
Walden, Helen ;
Muqit, Miratul M. K. .
EMBO REPORTS, 2015, 16 (08) :939-954
[6]   Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity [J].
Kumar, Atul ;
Chaugule, Viduth K. ;
Condos, Tara E. C. ;
Barber, Kathryn R. ;
Johnson, Clare ;
Toth, Rachel ;
Sundaramoorthy, Ramasubramanian ;
Knebel, Axel ;
Shaw, Gary S. ;
Walden, Helen .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2017, 24 (05) :475-+
[7]   Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis [J].
Kumar, Atul ;
Aguirre, Jacob D. ;
Condos, Tara E. C. ;
Martinez-Torres, R. Julio ;
Chaugule, Viduth K. ;
Toth, Rachel ;
Sundaramoorthy, Ramasubramanian ;
Mercier, Pascal ;
Knebel, Axel ;
Spratt, Donald E. ;
Barber, Kathryn R. ;
Shaw, Gary S. ;
Walden, Helen .
EMBO JOURNAL, 2015, 34 (20) :2506-2521
[8]   PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding [J].
Lazarou, Michael ;
Narendra, Derek P. ;
Jin, Seok Min ;
Tekle, Ephrem ;
Banerjee, Soojay ;
Youle, Richard J. .
JOURNAL OF CELL BIOLOGY, 2013, 200 (02) :163-172
[9]   Structure of a HOIP/E2∼ubiquitin complex reveals RBR E3 ligase mechanism and regulation [J].
Lechtenberg, Bernhard C. ;
Rajput, Akhil ;
Sanishvili, Ruslan ;
Dobaczewska, Malgorzata K. ;
Ware, Carl F. ;
Mace, Peter D. ;
Riedl, Stefan J. .
NATURE, 2016, 529 (7587) :546-+
[10]   Activation mechanisms of the E3 ubiquitin ligase parkin [J].
Panicker, Nikhil ;
Dawson, Valina L. ;
Dawson, Ted M. .
BIOCHEMICAL JOURNAL, 2017, 474 :3075-3086