Crohn's Disease: Potential Drugs for Modulation of Autophagy

被引：10

作者：

Azzman, Nursyuhada ^{[1
]}

机构：

[1] Univ Teknol MARA, Fac Pharm, Cawangan Pulau Pinang Kampus Bertam, Kepala Batas 13200, Pulau Pinang, Malaysia

来源：

MEDICINA-LITHUANIA | 2019年 / 55卷 / 06期

关键词：

autophagy; signalling pathways; Crohn's disease; drugs; adherent-invasive E; coli; inflammatory bowel disease; cytokines; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; INVASIVE ESCHERICHIA-COLI; GENOME-WIDE ASSOCIATION; HYDROGEN-SULFIDE; E; COLI; DOUBLE-BLIND; BUTYRATE; MACROPHAGES; SUSCEPTIBILITY; INDUCTION;

D O I：

10.3390/medicina55060224

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autophagy is an intracellular process whereby cytoplasmic constituents are degraded within lysosomes. Autophagy functions to eliminate unwanted or damaged materials such as proteins and organelles as their accumulation would be harmful to the cellular system. Autophagy also acts as a defense mechanism against invading pathogens and plays an important role in innate and adaptive immunity. In physiological processes, autophagy is involved in the regulation of tissue development, differentiation and remodeling, which are essential for maintaining cellular homeostasis. Recent studies have demonstrated that autophagy is linked to various diseases and involved in pathophysiological roles, such as adaptation during starvation, anti-aging, antigen presentation, tumor suppression and cell death. The modulation of autophagy has shown greatest promise in Crohn's disease as most of autophagy drugs involved in these diseases are currently under clinical trials and some has been approved by Food and Drug Administration. This review article discusses autophagy and potential drugs that are currently available for its modulation in Crohn's disease.

引用

页数：18

共 111 条

[31] Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia [J].