Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): Architecture

被引：64

作者：

Mandl, Kenneth D. ^{[1
,2
,3
,4
]}

Kohane, Isaac S. ^{[1
,2
,3
,4
]}

McFadden, Douglas ^{[2
,3
]}

Weber, Griffin M. ^{[2
,5
]}

Natter, Marc ^{[1
,4
]}

Mandel, Joshua ^{[1
,4
]}

Schneeweiss, Sebastian ^{[6
]}

Weiler, Sarah ^{[3
]}

Klann, Jeffrey G. ^{[7
]}

Bickel, Jonathan ^{[1
,4
,8
]}

Adams, William G. ^{[9
,10
]}

Ge, Yaorong ^{[11
]}

Zhou, Xiaobo ^{[12
]}

Perkins, James ^{[13
,14
]}

Marsolo, Keith ^{[15
]}

Bernstam, Elmer ^{[16
,17
]}

Showalter, John ^{[18
]}

Quarshie, Alexander ^{[19
,20
]}

Ofili, Elizabeth ^{[21
]}

Hripcsak, George ^{[22
]}

Murphy, Shawn N. ^{[7
,23
]}

机构：

[1] Harvard MIT Hlth Sci & Technol, Childrens Hosp Informat Program, Boston, MA USA

[2] Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA USA

[3] Harvard Univ, Sch Med, Harvard Catalyst, Boston, MA USA

[4] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[5] Beth Israel Deaconess Med Ctr, Biomed Res Informat Core, Boston, MA 02215 USA

[6] Brigham & Womens Hosp, Dept Med, Div Pharmacoepidemiol, Boston, MA 02115 USA

[7] Massachusetts Gen Hosp, Comp Sci Lab, Boston, MA 02114 USA

[8] Boston Childrens Hosp, Informat Serv Dept, Boston, MA 02115 USA

[9] Boston Univ, Sch Med, Boston Med Ctr, Boston, MA 02118 USA

[10] Boston Univ, Clin & Translat Sci Inst, Boston, MA 02215 USA

[11] Univ N Carolina, Coll Comp & Informat, Charlotte, NC 28223 USA

[12] Wake Forest Univ Hlth Sci, Ctr Bioinformat & Syst Biol, Dept Radiol, Winston Salem, NC USA

[13] Clark Atlanta Univ, Atlanta, GA 30314 USA

[14] Jackson State Univ, Data Coordinating Ctr, Res Ctr Minor Inst Translat Res Network, Jackson, MS USA

[15] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA

[16] Univ Texas Hlth Sci Ctr Houston, Div Biomed Informat, Houston, TX 77030 USA

[17] Univ Texas Hlth Sci Ctr Houston, Dept Internal Med, Houston, TX 77030 USA

[18] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA

[19] Morehouse Sch Med, Dept Internal Med Community Hlth & Prevent Med, Atlanta, GA 30310 USA

[20] Morehouse Sch Med, Clin Res Ctr, Atlanta, GA 30310 USA

[21] Morehouse Sch Med, Clin Res Ctr, Dept Internal Med, Atlanta, GA 30310 USA

[22] Columbia Univ, Dept Biomed Informat, New York, NY USA

[23] Partners HealthCare Syst, Informat Syst, Charlestown, MA USA

来源：

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION | 2014年 / 21卷 / 04期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

INFLAMMATORY-BOWEL-DISEASE; INTEGRATING BIOLOGY; INFORMATION ECONOMY; BEDSIDE; ARTHRITIS; OUTCOMES; REGISTRY; RECORDS; I2B2;

D O I：

10.1136/amiajnl-2014-002727

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

We describe the architecture of the Patient Centered Outcomes Research Institute (PCORI) funded Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS, http://www.SCILHS.org) clinical data research network, which leverages the $48 billion dollar federal investment in health information technology (IT) to enable a queryable semantic data model across 10 health systems covering more than 8 million patients, plugging universally into the point of care, generating evidence and discovery, and thereby enabling clinician and patient participation in research during the patient encounter. Central to the success of SCILHS is development of innovative 'apps' to improve PCOR research methods and capacitate point of care functions such as consent, enrollment, randomization, and outreach for patient-reported outcomes. SCILHS adapts and extends an existing national research network formed on an advanced IT infrastructure built with open source, free, modular components.

引用

页码：615 / 620

页数：6

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