Enhanced osteoconductivity of titanium implant by polarization-induced surface charges

被引:12
作者
Nozaki, Kosuke [1 ]
Wang, Wei [2 ]
Horiuchi, Naohiro [3 ]
Nakamura, Miho [3 ]
Takakuda, Kazuo [2 ]
Yamashita, Kimihiro [3 ]
Nagai, Akiko [1 ]
机构
[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Dept Mat Biofunct, Chiyoda Ku, Tokyo 1010062, Japan
[2] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Med & Dent Device Technol Incubat Ctr, Chiyoda Ku, Tokyo 1010062, Japan
[3] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Dept Inorgan Biomat, Chiyoda Ku, Tokyo 1010062, Japan
关键词
osseointegration; dental implant; surface modification; electrical polarization; micro-CT analysis; TRICALCIUM PHOSPHATE CERAMICS; MICRO-ARC OXIDATION; ELECTRICAL-POLARIZATION; CALCIUM-PHOSPHATE; BONE INGROWTH; HYDROXYAPATITE; OSSEOINTEGRATION; ACCELERATION; DETERMINANTS; INTEGRATION;
D O I
10.1002/jbm.a.34980
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
This study introduces the application of method for electrically polarizing titanium implants coated with anatase TiO2 using microarc oxidation. It also describes the features of the electrically polarized titanium implants, on which surface charges are generated by the dipole moment of the TiO2, and describes how the surface charges affect the implants' in vivo bone-implant integration capability. A comprehensive assessment using biomechanical, histomorphological, and radiographic analyses in a rabbit model was performed on polarized and nonpolarized implants. The electrically polarized surfaces accelerated the establishment of implant biomechanical fixation, compared with the nonpolarized surfaces. The percentage of the bone-implant contact ratio was higher using polarized implants than using nonpolarized implants. In contrast, the bone volume around the implants was not affected by polarization. Thus, using the polarized implant, this study identified that controlled surface charges have a significant effect on the properties of titanium implants. The application of the electrical polarization process and the polarization-enhanced osteoinductivity, which resulted in greater bone-implant integration, was clearly demonstrated. (C) 2013 Wiley Periodicals, Inc.
引用
收藏
页码:3077 / 3086
页数:10
相关论文
共 36 条
  • [1] The effect of ultraviolet functionalization of titanium on integration with bone
    Aita, Hideki
    Hori, Norio
    Takeuchi, Masato
    Suzuki, Takeo
    Yamada, Masahiro
    Anpo, Masakazu
    Ogawa, Takahiro
    [J]. BIOMATERIALS, 2009, 30 (06) : 1015 - 1025
  • [2] Albrektsson T, 2004, INT J PROSTHODONT, V17, P536
  • [3] ANDERSON HC, 1995, CLIN ORTHOP RELAT R, P266
  • [4] The effect of UV-photofunctionalization on the time-related bioactivity of titanium and chromium-cobalt alloys
    Att, Wael
    Hori, Norio
    Iwasa, Fuminori
    Yamada, Masahiro
    Ueno, Takeshi
    Ogawa, Takahiro
    [J]. BIOMATERIALS, 2009, 30 (26) : 4268 - 4276
  • [5] Baker D, 1999, INT J ORAL MAX IMPL, V14, P722
  • [6] Role of surface charge and wettability on early stage mineralization and bone cell-materials interactions of polarized hydroxyapatite
    Bodhak, Subhadip
    Bose, Susmita
    Bandyopadhyay, Amit
    [J]. ACTA BIOMATERIALIA, 2009, 5 (06) : 2178 - 2188
  • [7] The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation
    Boonrungsiman, Suwimon
    Gentleman, Eileen
    Carzaniga, Raffaella
    Evans, Nicholas D.
    McComb, David W.
    Porter, Alexandra E.
    Stevens, Molly M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (35) : 14170 - 14175
  • [8] INFLUENCE OF SURFACE CHARACTERISTICS ON BONE INTEGRATION OF TITANIUM IMPLANTS - A HISTOMORPHOMETRIC STUDY IN MINIATURE PIGS
    BUSER, D
    SCHENK, RK
    STEINEMANN, S
    FIORELLINI, JP
    FOX, CH
    STICH, H
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1991, 25 (07): : 889 - 902
  • [9] Biologic determinants of bone formation for osseointegration: Clues for future clinical improvements
    Cooper, LF
    [J]. JOURNAL OF PROSTHETIC DENTISTRY, 1998, 80 (04) : 439 - 449
  • [10] Classification of osseointegrated implant surfaces: materials, chemistry and topography
    Ehrenfest, David M. Dohan
    Coelho, Paulo G.
    Kang, Byung-Soo
    Sul, Young-Taeg
    Albrektsson, Tomas
    [J]. TRENDS IN BIOTECHNOLOGY, 2010, 28 (04) : 198 - 206