Research progress on the oxazolidinone drug linezolid resistance

被引:9
作者
Liu, B-G [1 ,2 ]
Yuan, X-L [3 ]
He, D-D [4 ]
Hu, G-Z [4 ]
Miao, M-S [1 ]
Xu, E-P [1 ]
机构
[1] Henan Univ Chinese Med, Acad Chinese Med Sci, Zhengzhou, Peoples R China
[2] Key Lab Modern Res Zhongjings Herbal Formulae Hen, Zhengzhou, Peoples R China
[3] Zhengzhou Univ, Neonatal Intens Care Unit, Affiliated Hosp 1, Zhengzhou, Peoples R China
[4] Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
Oxazolidinone; Linezolid; Resistance gene; OptrA; 23S RIBOSOMAL-RNA; STAPHYLOCOCCUS-AUREUS; ENTEROCOCCUS-FAECALIS; ESCHERICHIA-COLI; OPTRA GENE; 1ST REPORT; CFR; FAECIUM; ISOLATE; DISSEMINATION;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
OBJECTIVE: The oxazolidinone drug linezolid is mainly used for severe infections caused by multidrug-resistant Gram-positive bacteria. However, emerging linezolid resistance is aggravating difficulties in the treatment of certain infectious diseases. The objective of this review was to provide a reference for researchers and clinicians to be able to better face together the serious challenge of antimicrobial resistance. MATERIALS AND METHODS: A systematic literature search was performed using PubMed, Web of Science, Google Scholar, and the China National Knowledge Infrastructure (CNKI) database. The articles were scrutinized to extract information on oxazolidinone drug linezolid resistance, and the prevalence of the resistance gene optrA. We reviewed the latest advances in epidemic properties, resistance mechanism, and transfer mechanism of linezolid resistance genes in different isolates isolated from various samples worldwide. RESULTS: Initially, it was thought that linezolid resistance was related to the change in drug target mediated by mutations in the 23S rRNA gene, rp1C, rp1D, and cfr. optrA was discovered in 2015, and is a gene encoding oxazolidinone resistance, which exists in both plasmids and chromosomes, but mostly plasmids. The emergence of the novel plasmid-borne ABC transporter gene optrA expanded the understanding of the mechanism of linezolid resistance. CONCLUSIONS: At present, the prevalence of linezolid resistance has become increasingly serious. The resistance gene optrA has been reported in Enterococcus, Staphylococcus squirrel and Streptococcus, which indicates that this gene has a strong ability to spread across bacteria, so the prevalence and spread of optrA gene should be monitored carefully.
引用
收藏
页码:9274 / 9281
页数:8
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